Center for Bioinformatics
Oxidoreductases | Transferases | Hydrolases | Lyases | Isomerases | Ligases

Basic Information

Enzyme Number

5.2.1.8

Official Name

peptidylprolyl isomerase

Name from literature

prolyl cis trans isomerase

Pathway from literature

protein-folding

Pathway from KEGG

Environmental Information Processing; Signal Transduction; Calcium signaling pathway; map04020

Genetic Information Processing; Folding, Sorting and Degradation; Ubiquitin mediated proteolysis; map04120

Organisms

E.coli (83333)

Genome localization

-[944807 ], -[946056 ], -[948285 ], -[947859 ], -[947850 ], -[948726 ], -[944812 ], -[947870 ], -[949038 ],

Comments

The first type of this enzyme found [1] proved to be the protein cyclophilin, which binds the immunosuppressant cyclosporin A. Other distinct families of the enzyme exist, one being FK-506 binding proteins (FKBP) and another that includes parvulin from Escherichia coli. The three families are structurally unrelated and can be distinguished by being inhibited by cyclosporin A, FK-506 and 5-hydroxy-1,4-naphthoquinone, respectively.

Rate-limiting Description

"Peptidyl-prolyl cis-trans isomerization is known to be a rate-limiting step in protein-folding and is slower at low temperature." (12119099)

Gene ontology

Gene ontology

GO:0008270 (F) zinc ion binding [P0A9K9 ];
GO:0006950 (P) response to stress [P0ADY1 ];
GO:0005886 (C) plasma membrane [P0ADY1 ];
GO:0005829 (C) cytosol [P0A9L3 ];
GO:0005737 (C) cytoplasm [P23869, P0A9K9, P0A9L5 ];
GO:0006457 (P) protein folding [P45523, P0ABZ6, P23869, P0AEM0, P0ADY1, P0A9K9, P0AFL3, P0A9L5, P0A9L3 ];
GO:0016021 (C) integral to membrane [P0ADY1 ];
GO:0005507 (F) copper ion binding [P0A9K9 ];
GO:0050897 (F) cobalt ion binding [P0A9K9 ];
GO:0051082 (F) unfolded protein binding [P0ABZ6 ];
GO:0003755 (F) peptidyl-prolyl cis-trans isomerase activity [P45523, P0ABZ6, P23869, P0AEM0, P0ADY1, P0A9K9, P0AFL3, P0A9L5, P0A9L3 ];
GO:0016151 (F) nickel ion binding [P0A9K9 ];
GO:0005515 (F) protein binding [P0A9K9 ];
GO:0042597 (C) periplasmic space [P45523, P0ABZ6, P0ADY1, P0AFL3, P0A9L3 ];

Subcellular localization

Localization

cell membrane [P0ADY1 ];

cytoplasm [P23869, P0A9K9, P0A9L5, P0A9L3 ];

Links

SwissProt

P0A9K9; P0A9L3; P0A9L5; P0ABZ6; P0ADY1; P0AEM0; P0AFL3; P23869; P45523

Entrez Gene

944807; 944812; 946056; 947850; 947859; 947870; 948285; 948726; 949038



  Copyright 2009, Center for Bioinformatics 
  Last Modified: 2009-03-24  
  Design by Zhao Min