Center for Bioinformatics
Oxidoreductases | Transferases | Hydrolases | Lyases | Isomerases | Ligases

Basic Information

Enzyme Number

1.2.4.2/2.3.1.61/1.8.1.4

Official Name

dihydrolipoyllysine-residue succinyltransferase

Name from literature

oxoglutarate dehydrogenase complex

Pathway from literature

citric acid cycle

Pathway from KEGG

Carbohydrate Metabolism; Pyruvate metabolism; map00620

Carbohydrate Metabolism; Glycolysis / Gluconeogenesis; map00010

Carbohydrate Metabolism; Citrate cycle (TCA cycle); map00020

Amino Acid Metabolism; Tryptophan metabolism; map00380

Amino Acid Metabolism; Glycine, serine and threonine metabolism; map00260

Amino Acid Metabolism; Valine, leucine and isoleucine degradation; map00280

Amino Acid Metabolism; Lysine degradation; map00310

Amino Acid Metabolism; Alanine and aspartate metabolism; map00252

Organisms

E.coli (83333)

Genome localization

-[945307 ], -[944854 ], -[945303 ],

Comments

A multimer (24-mer) of this enzyme forms the core of the multienzyme complex, and binds tightly both EC 1.2.4.2, oxoglutarate dehydrogenase (succinyl-transferring) and EC 1.8.1.4, dihydrolipoyl dehydrogenase. The lipoyl group of this enzyme is reductively succinylated by EC 1.2.4.2, and the only observed direction catalysed by EC 2.3.1.61 is that where this succinyl group is passed to coenzyme A.

Rate-limiting Description

"The thiamine-dependent E1o component (EC 1.2.4.2) of the 2-oxoglutarate dehydrogenase complex catalyses a rate-limiting step of the tricarboxylic acid cycle (TCA) of aerobically respiring organisms." (17367808)

Gene ontology

Gene ontology

GO:0050660 (F) FAD binding [P0A9P0 ];
GO:0006096 (P) glycolysis [P0A9P0, P0AFG3 ];
GO:0005829 (C) cytosol [P0A9P0, P0AFG3 ];
GO:0045252 (C) oxoglutarate dehydrogenase complex [P0AFG6 ];
GO:0004148 (F) dihydrolipoyl dehydrogenase activity [P0A9P0 ];
GO:0031405 (F) lipoic acid binding [P0AFG6 ];
GO:0006099 (P) tricarboxylic acid cycle [P0AFG6 ];
GO:0009055 (F) electron carrier activity [P0A9P0 ];
GO:0045454 (P) cell redox homeostasis [P0A9P0 ];
GO:0004591 (F) oxoglutarate dehydrogenase (succinyl-transf... [P0AFG3 ];
GO:0030976 (F) thiamin pyrophosphate binding [P0AFG3 ];
GO:0005515 (F) protein binding [P0A9P0, P0AFG6 ];
GO:0005739 (C) mitochondrion [P0A9P0 ];
GO:0005886 (C) plasma membrane [P0A9P0 ];
GO:0055114 (P) oxidation reduction [P0A9P0, P0AFG3 ];
GO:0004149 (F) dihydrolipoyllysine-residue succinyltransfe... [P0AFG6 ];

Subcellular localization

Localization

cell membrane [P0A9P0 ];

cytoplasm [P0A9P0 ];

Links

SwissProt

P0AFG3; P0A9P0; P0AFG6

Entrez Gene

945303; 944854; 945307



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  Last Modified: 2009-03-24  
  Design by Zhao Min