Center for Bioinformatics
Oxidoreductases | Transferases | Hydrolases | Lyases | Isomerases | Ligases

Basic Information

Enzyme Number

1.14.15.6

Official Name

cholesterol monooxygenase (side-chain-cleaving)

Name from literature

P450scc

Pathway from literature

steroid synthesis

Pathway from KEGG

Lipid Metabolism; C21-Steroid hormone metabolism; map00140

Organisms

Mouse (10090)

Genome localization

9 B|9 31.0 cM[13070 ],

Comments

A heme-thiolate protein. The reaction proceeds in three stages, with hydroxylation at C-20 and C-22 preceding scission of the side-chain at C-20.

Rate-limiting Description

"StAR protein mediates the rate-limiting and acutely regulated step in steroidogenesis, the transfer of cholesterol from the outer to the inner mitochondrial membrane where the cytochrome P450 side chain cleavage (P450scc) enzyme initiates the synthesis of all steroid hormones." (10964798)

Gene ontology

Gene ontology

GO:0008386 (F) cholesterol monooxygenase (side-chain-cleav... [Q9QZ82 ];
GO:0009055 (F) electron carrier activity [Q9QZ82 ];
GO:0006700 (P) C21-steroid hormone biosynthetic process [Q9QZ82 ];
GO:0008203 (P) cholesterol metabolic process [Q9QZ82 ];
GO:0055114 (P) oxidation reduction [Q9QZ82 ];
GO:0020037 (F) heme binding [Q9QZ82 ];
GO:0005506 (F) iron ion binding [Q9QZ82 ];

Subcellular localization

Localization

mitochondrion [Q9QZ82 ];

Links

SwissProt

Q9QZ82

Entrez Gene

13070



  Copyright 2009, Center for Bioinformatics 
  Last Modified: 2009-03-24  
  Design by Zhao Min