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Oxidoreductases | Transferases | Hydrolases | Lyases | Isomerases | Ligases |
Basic Information |
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Enzyme Number | 6.3.2.2 |
Official Name | glutamate---cysteine ligase |
Name from literature | gamma-glutamylcysteine synthetase(gamma-GCShs) |
Pathway from literature | glutathione synthesis |
Pathway from KEGG |
Metabolism of Other Amino Acids; Glutathione metabolism; map00480 |
Amino Acid Metabolism; Glutamate metabolism; map00251 | |
Organisms | Rat (10116) |
Genome localization | 8q31[25283 ], |
Comments | Can use L-aminohexanoate in place of glutamate. |
Rate-limiting Description | "In glial cells, incubation with 6-OHDA and H2O2 induced a significant increase in the expression of gamma-glutamylcysteine synthetase (the rate-limiting enzyme in glutathione synthesis) mRNA, which correlated well with increased TPA-response element (TRE)-binding activity." (10349842) |
Gene ontology |
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Gene ontology |
GO:0006536 (P) glutamate metabolic process [P19468 ]; |
Links |
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SwissProt | |
Entrez Gene |
Copyright 2009, Center for Bioinformatics | |||
Last Modified: 2009-03-24 | |||
Design by Zhao Min |