Center for Bioinformatics
Oxidoreductases | Transferases | Hydrolases | Lyases | Isomerases | Ligases

Basic Information

Enzyme Number

6.3.2.2

Official Name

glutamate---cysteine ligase

Name from literature

gamma-glutamylcysteine synthetase(gamma-GCShs)

Pathway from literature

glutathione synthesis

Pathway from KEGG

Metabolism of Other Amino Acids; Glutathione metabolism; map00480

Amino Acid Metabolism; Glutamate metabolism; map00251

Organisms

Rat (10116)

Genome localization

8q31[25283 ],

Comments

Can use L-aminohexanoate in place of glutamate.

Rate-limiting Description

"In glial cells, incubation with 6-OHDA and H2O2 induced a significant increase in the expression of gamma-glutamylcysteine synthetase (the rate-limiting enzyme in glutathione synthesis) mRNA, which correlated well with increased TPA-response element (TRE)-binding activity." (10349842)

Gene ontology

Gene ontology

GO:0006536 (P) glutamate metabolic process [P19468 ];
GO:0004357 (F) glutamate-cysteine ligase activity [P19468 ];
GO:0000287 (F) magnesium ion binding [P19468 ];
GO:0043531 (F) ADP binding [P19468 ];
GO:0050880 (P) regulation of blood vessel size [P19468 ];
GO:0016595 (F) glutamate binding [P19468 ];
GO:0050662 (F) coenzyme binding [P19468 ];
GO:0009725 (P) response to hormone stimulus [P19468 ];
GO:0006979 (P) response to oxidative stress [P19468 ];
GO:0009408 (P) response to heat [P19468 ];
GO:0016481 (P) negative regulation of transcription [P19468 ];
GO:0006750 (P) glutathione biosynthetic process [P19468 ];
GO:0006916 (P) anti-apoptosis [P19468 ];
GO:0045454 (P) cell redox homeostasis [P19468 ];
GO:0006534 (P) cysteine metabolic process [P19468 ];

Links

SwissProt

P19468

Entrez Gene

25283



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  Last Modified: 2009-03-24  
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