6.3.2.2

glutamate---cysteine ligase

gamma-glutamylcysteine synthetase(gamma-GCShs)

glutathione synthesis

Rat (10116)

8q31[25283 ],

Can use L-aminohexanoate in place of glutamate.

"In glial cells, incubation with 6-OHDA and H2O2 induced a significant increase in the expression of gamma-glutamylcysteine synthetase (the rate-limiting enzyme in glutathione synthesis) mRNA, which correlated well with increased TPA-response element (TRE)-binding activity." (10349842)

GO:0006536 (P) glutamate metabolic process [P19468 ];
GO:0004357 (F) glutamate-cysteine ligase activity [P19468 ];
GO:0000287 (F) magnesium ion binding [P19468 ];
GO:0043531 (F) ADP binding [P19468 ];
GO:0050880 (P) regulation of blood vessel size [P19468 ];
GO:0016595 (F) glutamate binding [P19468 ];
GO:0050662 (F) coenzyme binding [P19468 ];
GO:0009725 (P) response to hormone stimulus [P19468 ];
GO:0006979 (P) response to oxidative stress [P19468 ];
GO:0009408 (P) response to heat [P19468 ];
GO:0016481 (P) negative regulation of transcription [P19468 ];
GO:0006750 (P) glutathione biosynthetic process [P19468 ];
GO:0006916 (P) anti-apoptosis [P19468 ];
GO:0045454 (P) cell redox homeostasis [P19468 ];
GO:0006534 (P) cysteine metabolic process [P19468 ];

P19468

25283