Center for Bioinformatics
Oxidoreductases | Transferases | Hydrolases | Lyases | Isomerases | Ligases

Basic Information

Enzyme Number

6.4.1.2

Official Name

acetyl-CoA carboxylase

Name from literature

acetyl CoA carboxylase

Pathway from literature

the de novo synthesis of lipids and cholesterol

Pathway from KEGG

Biosynthesis of Secondary Metabolites; Tetracycline biosynthesis; map00253

Cellular Processes; Endocrine System; Insulin signaling pathway; map04910

Carbohydrate Metabolism; Pyruvate metabolism; map00620

Carbohydrate Metabolism; Propanoate metabolism; map00640

Lipid Metabolism; Fatty acid biosynthesis; map00061

Organisms

Yeast (4932)

Genome localization

-[855750 ],

Comments

A biotinyl-protein. Also catalyses transcarboxylation; the plant enzyme also carboxylates propanonyl-CoA and butanoyl-CoA.

Rate-limiting Description

"We report that mutants with conditional defects in the rate-limiting enzyme of fatty acid synthesis, acetyl coenzyme A carboxylase (ACC1), display unusually multilobed vacuoles, similar to those observed in vac8 mutant cells." (10757783)

Gene ontology

Gene ontology

GO:0030145 (F) manganese ion binding [Q00955 ];
GO:0005739 (C) mitochondrion [Q00955, P32874 ];
GO:0009374 (F) biotin binding [Q00955, P32874 ];
GO:0004075 (F) biotin carboxylase activity [Q00955, P32874 ];
GO:0003989 (F) acetyl-CoA carboxylase activity [Q00955, P32874 ];
GO:0006606 (P) protein import into nucleus [Q00955 ];
GO:0005789 (C) endoplasmic reticulum membrane [Q00955 ];
GO:0006633 (P) fatty acid biosynthetic process [Q00955, P32874 ];
GO:0005524 (F) ATP binding [Q00955, P32874 ];
GO:0006998 (P) nuclear membrane organization [Q00955 ];

Subcellular localization

Localization

mitochondrion [P32874 ];

cytoplasm [Q00955 ];

Links

SwissProt

P32874; Q00955

Entrez Gene

855750



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  Last Modified: 2009-03-24  
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