Center for Bioinformatics
Oxidoreductases | Transferases | Hydrolases | Lyases | Isomerases | Ligases

Basic Information

Enzyme Number

1.3.3.6

Official Name

acyl-CoA oxidase

Name from literature

acyl CoA oxidase

Pathway from literature

very-long-chain fatty acid peroxisomal oxidation

Pathway from KEGG

Lipid Metabolism; Fatty acid metabolism; map00071

Cellular Processes; Endocrine System; PPAR signaling pathway; map03320

Lipid Metabolism; Biosynthesis of unsaturated fatty acids; map01040

Lipid Metabolism; alpha-Linolenic acid metabolism; map00592

Organisms

Mouse (10090)

Genome localization

-[80911 ], 11 E2[11430 ],

Comments

A flavoprotein (FAD). Acts on CoA derivatives of fatty acids with chain lengths from 8 to 18.

Rate-limiting Description

"Straight-chain acyl-CoA oxidase (AOX) catalyzes the first, rate-limiting step of peroxisomal beta-oxidation of very-long-chain saturated and unsaturated fatty acids." (11855929)

"The biologic role of peroxisomal beta-oxidation system, which consists of three enzymes: fatty acyl-CoA oxidase (ACOX), enoyl-CoA hydratase/3-hydroxyacyl-CoA dehydrogenase (HD), and thiolase, has been examined in mice by disrupting ACOX gene, which encodes the first and rate-limiting enzyme of this system." (8798738)

"Straight-chain acyl-CoA oxidase is the first and rate limiting enzyme in the peroxisomal beta-oxidation pathway catalysing the desaturation of acyl-CoAs to 2-trans-enoyl-CoAs, thereby producing H2O2." (10672038)

"Our results show that in healthy mice a low dietary DHA dose (< 0.2%; this corresponds to a dose prescribed to peroxisomal patients) has no effect on several hepatic peroxisomal H2O2-producing enzymes, including the rate-limiting enzyme of the peroxisomal fatty acid beta-oxidation." (8934448)

"Etomoxir administration for 1 day significantly increased (4.4-fold induction) the mRNA expression of acyl-CoA oxidase (ACO), which catalyzes the rate-limiting step in peroxisomal beta-oxidation." (12576521)

Regulatory Information

Upstream transcription factor

20850;19013

Regulatory type

Detail

phosphorylation;

Q9R0H0

phosphorylation;

Q9R0H0:from_uniprot:26_Phosphoserine

phosphorylation;

Q9R0H0:from_uniprot:310_Phosphoserine

phosphorylation;

Q9R0H0:from_uniprot:649_Phosphoserine

transcriptional factor;STAT5A(20850)

"STAT5A binds to -1841 to -1825 of the murine AOX promoter." (16650827)

transcriptional factor;PPAR(19013)

"The mRNA profiles of BMAL1 and of the PPAR target genes acyl-CoA oxidase (AOX), 3-hydroxy-3-methylglutaryl coenzyme A (HMG-CoA) synthase and cellular retinol binding protein II (CRBPII) were measured in intestine. " (16650827)

Gene ontology

Gene ontology

GO:0050660 (F) FAD binding [Q9EPL9, Q9R0H0 ];
GO:0016402 (F) pristanoyl-CoA oxidase activity [Q9EPL9 ];
GO:0006635 (P) fatty acid beta-oxidation [Q9EPL9, Q9R0H0 ];
GO:0005739 (C) mitochondrion [Q9R0H0 ];
GO:0003995 (F) acyl-CoA dehydrogenase activity [Q9EPL9, Q9R0H0 ];
GO:0005778 (C) peroxisomal membrane [Q9R0H0 ];
GO:0009055 (F) electron carrier activity [Q9EPL9, Q9R0H0 ];
GO:0007283 (P) spermatogenesis [Q9R0H0 ];
GO:0005782 (C) peroxisomal matrix [Q9EPL9 ];
GO:0055114 (P) oxidation reduction [Q9EPL9, Q9R0H0 ];
GO:0003997 (F) acyl-CoA oxidase activity [Q9R0H0 ];

Subcellular localization

Localization

peroxisome [Q9EPL9, Q9R0H0 ];

Links

SwissProt

Q9EPL9; Q9R0H0

Entrez Gene

11430; 80911



  Copyright 2009, Center for Bioinformatics 
  Last Modified: 2009-03-24  
  Design by Zhao Min