Center for Bioinformatics
Oxidoreductases | Transferases | Hydrolases | Lyases | Isomerases | Ligases

Basic Information

Enzyme Number

Official Name

thymidylate synthase

Name from literature

Thymidylate synthase

Pathway from literature

the synthesis of pyrimidine nucleotides

Pathway from KEGG

Metabolism of Cofactors and Vitamins; One carbon pool by folate; map00670

Nucleotide Metabolism; Pyrimidine metabolism; map00240


Mouse (10090)

Genome localization

5 B1|5 18.2 cM[22171 ],

Rate-limiting Description

"Activation energy for the reaction, catalyzed by thymidylate synthase from mouse tumour but not from mouse thymus, lowers at temperatures above 34 degrees C, reflecting a change of rate-limiting step in dTMP formation." (3709927)

Regulatory Information

Upstream transcription factor


Regulatory type


transcriptional factor;"GABP(14390),Sp1(20683)"

"Synergistic activation of the TATA-less thymidylate synthase promoter by the Ets transcription factor GABP and Sp1." (11855856)

Gene ontology

Gene ontology

GO:0006231 (P) dTMP biosynthetic process [Q8VDV6, Q544L2, Q9D0H1, Q8C2H6, P07607, Q8C2R3 ];
GO:0004799 (F) thymidylate synthase activity [Q8VDV6, Q544L2, Q9D0H1, Q8C2H6, P07607, Q8C2R3 ];



P07607; Q544L2; Q8C2H6; Q8C2R3; Q8VDV6; Q9D0H1

Entrez Gene


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  Last Modified: 2009-03-24  
  Design by Zhao Min