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| Oxidoreductases | Transferases | Hydrolases | Lyases | Isomerases | Ligases |
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Basic Information |
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Enzyme Number | 2.1.1.45 |
Official Name | thymidylate synthase |
Name from literature | Thymidylate synthase |
Pathway from literature | the synthesis of pyrimidine nucleotides |
Pathway from KEGG |
Metabolism of Cofactors and Vitamins; One carbon pool by folate; map00670 |
| Nucleotide Metabolism; Pyrimidine metabolism; map00240 | |
Organisms | Mouse (10090) |
Genome localization | 5 B1|5 18.2 cM[22171 ], |
Rate-limiting Description | "Activation energy for the reaction, catalyzed by thymidylate synthase from mouse tumour but not from mouse thymus, lowers at temperatures above 34 degrees C, reflecting a change of rate-limiting step in dTMP formation." (3709927) |
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Regulatory Information |
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Upstream transcription factor | |
Regulatory type | Detail |
transcriptional factor;"GABP(14390),Sp1(20683)" | "Synergistic activation of the TATA-less thymidylate synthase promoter by the Ets transcription factor GABP and Sp1." (11855856) |
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Gene ontology |
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Gene ontology |
GO:0006231 (P) dTMP biosynthetic process [Q8VDV6, Q544L2, Q9D0H1, Q8C2H6, P07607, Q8C2R3 ]; |
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Links |
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SwissProt | |
Entrez Gene |