Center for Bioinformatics
Oxidoreductases | Transferases | Hydrolases | Lyases | Isomerases | Ligases

Basic Information

Enzyme Number

2.1.1.45

Official Name

thymidylate synthase

Name from literature

Thymidylate synthase

Pathway from literature

the synthesis of pyrimidine nucleotides

Pathway from KEGG

Metabolism of Cofactors and Vitamins; One carbon pool by folate; map00670

Nucleotide Metabolism; Pyrimidine metabolism; map00240

Organisms

Mouse (10090)

Genome localization

5 B1|5 18.2 cM[22171 ],

Rate-limiting Description

"Activation energy for the reaction, catalyzed by thymidylate synthase from mouse tumour but not from mouse thymus, lowers at temperatures above 34 degrees C, reflecting a change of rate-limiting step in dTMP formation." (3709927)

Regulatory Information

Upstream transcription factor

14390;20683

Regulatory type

Detail

transcriptional factor;"GABP(14390),Sp1(20683)"

"Synergistic activation of the TATA-less thymidylate synthase promoter by the Ets transcription factor GABP and Sp1." (11855856)

Gene ontology

Gene ontology

GO:0006231 (P) dTMP biosynthetic process [Q8VDV6, Q544L2, Q9D0H1, Q8C2H6, P07607, Q8C2R3 ];
GO:0004799 (F) thymidylate synthase activity [Q8VDV6, Q544L2, Q9D0H1, Q8C2H6, P07607, Q8C2R3 ];

Links

SwissProt

P07607; Q544L2; Q8C2H6; Q8C2R3; Q8VDV6; Q9D0H1

Entrez Gene

22171



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  Last Modified: 2009-03-24  
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