Center for Bioinformatics
Oxidoreductases | Transferases | Hydrolases | Lyases | Isomerases | Ligases

Basic Information

Enzyme Number

Official Name

argininosuccinate synthase

Name from literature

argininosuccinic acid synthetase

Pathway from literature

urea production/urea cycle

Pathway from KEGG

Amino Acid Metabolism; Urea cycle and metabolism of amino groups; map00220

Amino Acid Metabolism; Arginine and proline metabolism; map00330

Amino Acid Metabolism; Alanine and aspartate metabolism; map00252


Rat (10116)

Genome localization

3p12[25698 ],

Rate-limiting Description

"Control experiments (sham-operated, starved rats) revealed that the activities of only two enzymes of the cycle are altered in the uraemic state: argininosuccinic acid synthetase (EC, which is considered to be rate limiting for urea production and carbamyl phosphate synthetase (EC" (1122920)

Regulatory Information

Upstream transcription factor


Regulatory type




transcriptional factor;IFN gamma(25712)

"It has been shown in other cell types that interferon-gamma (IFN gamma) and bacterial lipopolysaccharide induce the enzyme argininosuccinate synthetase (AS), enhancing the capacity of these cells to regenerate arginine from citrulline and maintain NO production in the presence of low arginine concentrations." (7628352)

Gene ontology

Gene ontology

GO:0006526 (P) arginine biosynthetic process [P09034 ];
GO:0004055 (F) argininosuccinate synthase activity [P09034 ];
GO:0000050 (P) urea cycle [P09034 ];
GO:0005524 (F) ATP binding [P09034 ];




Entrez Gene


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  Last Modified: 2009-03-24  
  Design by Zhao Min