Center for Bioinformatics
Oxidoreductases | Transferases | Hydrolases | Lyases | Isomerases | Ligases

Basic Information

Enzyme Number

6.3.4.5

Official Name

argininosuccinate synthase

Name from literature

argininosuccinic acid synthetase

Pathway from literature

urea production/urea cycle

Pathway from KEGG

Amino Acid Metabolism; Urea cycle and metabolism of amino groups; map00220

Amino Acid Metabolism; Arginine and proline metabolism; map00330

Amino Acid Metabolism; Alanine and aspartate metabolism; map00252

Organisms

Mouse (10090)

Genome localization

2 B|2 20.0 cM[11898 ],

Rate-limiting Description

"We investigated the induction of iNOS together with argininosuccinate synthase (AS) and GTP cyclohydrolase I (GTPCH), 2 of the rate-limiting enzymes for high output NO generation, in the Tg197 h-TNF-alpha transgenic model of arthritis." (12672181)

Regulatory Information

Regulatory type

Detail

phosphorylation;

P16460

phosphorylation;

P16460:from_uniprot:352_Phosphoserine

transcriptional level;TNF alpha(21926)

"Induction of inducible nitric oxide synthase, argininosuccinate synthase, and GTP cyclohydrolase I in arthritic joints of human tumor necrosis factor-alpha transgenic mice." (12672181)

Gene ontology

Gene ontology

GO:0006526 (P) arginine biosynthetic process [Q3UJ34, Q3UEJ7, P16460 ];
GO:0005739 (C) mitochondrion [P16460 ];
GO:0004055 (F) argininosuccinate synthase activity [Q3UJ34, Q3UEJ7, P16460 ];
GO:0000050 (P) urea cycle [P16460 ];
GO:0005524 (F) ATP binding [Q3UJ34, Q3UEJ7, P16460 ];

Links

SwissProt

P16460; Q3UEJ7; Q3UJ34

Entrez Gene

11898



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  Last Modified: 2009-03-24  
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