Center for Bioinformatics
Oxidoreductases | Transferases | Hydrolases | Lyases | Isomerases | Ligases

Basic Information

Enzyme Number

2.7.1.11

Official Name

6-phosphofructokinase

Name from literature

phosphofructokinase

Pathway from literature

glycolysis

Pathway from KEGG

Cellular Processes; Endocrine System; Insulin signaling pathway; map04910

Carbohydrate Metabolism; Fructose and mannose metabolism; map00051

Carbohydrate Metabolism; Pentose phosphate pathway; map00030

Carbohydrate Metabolism; Glycolysis / Gluconeogenesis; map00010

Carbohydrate Metabolism; Galactose metabolism; map00052

Organisms

Mouse (10090)

Genome localization

13 A1[56421 ], 10 C1|10 41.7 cM[18641 ], 15 F1[18642 ],

Comments

D-Tagatose 6-phosphate and sedoheptulose 7-phosphate can act as acceptors. UTP, CTP and ITP can act as donors. Not identical with EC 2.7.1.105 6-phosphofructo-2-kinase.

Rate-limiting Description

"Intracellular distribution of cytoskeleton-bound and soluble phosphofructokinase (PFK) (the rate-limiting enzyme in glycolysis) in mdx dystrophic muscle was the same as in control nondystrophic muscle." (1828673)

Regulatory Information

Regulatory type

Detail

phosphorylation;

P12382

phosphorylation;

P47857

phosphorylation;

Q9WUA3

phosphorylation;

P12382:from_uniprot:640_Phosphotyrosine

phosphorylation;

P47857:from_uniprot:2_Phosphothreonine

phosphorylation;

P47857:from_uniprot:775_Phosphoserine

phosphorylation;

Q9WUA3:from_uniprot:650_Phosphotyrosine

transcriptional factor;

"Additional conserved elements were found further upstream at the 5'-region of both the human and mouse genes. They consisted of two Alu repeats and several sequence motifs known to serve as transcription factors binding sites." (7549935#1850735)

Gene ontology

Gene ontology

GO:0000287 (F) magnesium ion binding [P12382, Q9WUA3, P47857 ];
GO:0005945 (C) 6-phosphofructokinase complex [P12382, Q9WUA3, P47857 ];
GO:0003872 (F) 6-phosphofructokinase activity [P12382, Q9WUA3, P47857 ];
GO:0006096 (P) glycolysis [P12382, Q9WUA3, P47857 ];
GO:0006002 (P) fructose 6-phosphate metabolic process [P12382 ];
GO:0005524 (F) ATP binding [P12382, Q9WUA3, P47857 ];

Links

SwissProt

P12382; P47857; Q9WUA3

Entrez Gene

18641; 18642; 56421



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  Last Modified: 2009-03-24  
  Design by Zhao Min