Center for Bioinformatics
Oxidoreductases | Transferases | Hydrolases | Lyases | Isomerases | Ligases

Basic Information

Enzyme Number

3.1.1.34

Official Name

lipoprotein lipase

Name from literature

Lipoprotein lipase

Pathway from literature

the hydrolysis of triglyceride-rich lipoproteins and plays an important role in glucose metabolism

Pathway from KEGG

Lipid Metabolism; Glycerolipid metabolism; map00561

Human Diseases; Neurodegenerative Diseases; Alzheimer's disease; map05010

Cellular Processes; Endocrine System; PPAR signaling pathway; map03320

Organisms

Rat (10116)

Genome localization

16p14[24539 ],

Comments

Hydrolyses triacylglycerols in chylomicrons and low-density lipoproteins. Also hydrolyses diacylglycerol.

Rate-limiting Description

"Lipoprotein lipase (LpL) is the rate limiting enzyme for lipolysis of TG." (11158876)

"Vascular endothelium-bound lipoprotein lipase (LPL) is rate limiting for free fatty acid (FFA) transport into tissues." (10364085)

Regulatory Information

Upstream transcription factor

25747

Regulatory type

Detail

transcriptional factor;PPARalpha(25747)

"PPAR-gamma activation mediates adipose depot-specific effects on gene expression and activity of this enzyme." (12540599)

transcriptional factor;PPARalpha(25747)

"hormonal and nutritional induction of liver PPAR-alpha expression around birth and its maintained elevated level throughout suckling is responsible for the induction of liver LPL-expression and activity during suckling" (17451160)

phosphorylation;

"Administration of resistin to adipocytes mimicked the effects of GIP on the PKB/LKB1/AMPK/LPL pathway: increasing phosphorylation of PKB, reducing levels of phosphorylated LKB1 and AMPK, and increasing LPL activity." (17890220)

Gene ontology

Gene ontology

GO:0042627 (C) chylomicron [Q06000 ];
GO:0005319 (F) lipid transporter activity [Q06000 ];
GO:0031225 (C) anchored to membrane [Q06000 ];
GO:0016042 (P) lipid catabolic process [Q06000 ];
GO:0008201 (F) heparin binding [Q06000 ];
GO:0005886 (C) plasma membrane [Q06000 ];
GO:0004465 (F) lipoprotein lipase activity [Q06000 ];

Subcellular localization

Localization

cell membrane [Q06000 ];

Links

SwissProt

Q06000

Entrez Gene

24539



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  Last Modified: 2009-03-24  
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