3.1.1.34

lipoprotein lipase

Lipoprotein lipase

the hydrolysis of triglyceride-rich lipoproteins and plays an important role in glucose metabolism

Mouse (10090)

-[669888 ], 8 B3.3|8 33.0 cM[16956 ],

Hydrolyses triacylglycerols in chylomicrons and low-density lipoproteins. Also hydrolyses diacylglycerol.

"The tissue-specific expression of lipoprotein lipase (LPL) in adipose tissue (AT), skeletal muscle (SM), and cardiac muscle (CM) is rate-limiting for the uptake of triglyceride (TG)-derived free fatty acids and decisive in the regulation of energy balance and lipoprotein metabolism." (10077655)

phosphorylation;

"Administration of resistin to adipocytes mimicked the effects of GIP on the PKB/LKB1/AMPK/LPL pathway: increasing phosphorylation of PKB, reducing levels of phosphorylated LKB1 and AMPK, and increasing LPL activity." (17890220)

GO:0031225 (C) anchored to membrane [P11152 ];
GO:0005886 (C) plasma membrane [P11152 ];
GO:0004465 (F) lipoprotein lipase activity [P11152 ];
GO:0019433 (P) triacylglycerol catabolic process [P11152 ];
GO:0005319 (F) lipid transporter activity [P11152 ];
GO:0042627 (C) chylomicron [P11152 ];
GO:0004806 (F) triacylglycerol lipase activity [P11152 ];
GO:0008201 (F) heparin binding [P11152 ];
GO:0017129 (F) triglyceride binding [P11152 ];

cell membrane [P11152 ];

P11152

16956; 669888