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Oxidoreductases | Transferases | Hydrolases | Lyases | Isomerases | Ligases |
Basic Information |
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Enzyme Number | 3.1.1.34 |
Official Name | lipoprotein lipase |
Name from literature | Lipoprotein lipase |
Pathway from literature | the hydrolysis of triglyceride-rich lipoproteins and plays an important role in glucose metabolism |
Pathway from KEGG |
Lipid Metabolism; Glycerolipid metabolism; map00561 |
Human Diseases; Neurodegenerative Diseases; Alzheimer's disease; map05010 | |
Cellular Processes; Endocrine System; PPAR signaling pathway; map03320 | |
Organisms | Mouse (10090) |
Genome localization | |
Comments | Hydrolyses triacylglycerols in chylomicrons and low-density lipoproteins. Also hydrolyses diacylglycerol. |
Rate-limiting Description | "The tissue-specific expression of lipoprotein lipase (LPL) in adipose tissue (AT), skeletal muscle (SM), and cardiac muscle (CM) is rate-limiting for the uptake of triglyceride (TG)-derived free fatty acids and decisive in the regulation of energy balance and lipoprotein metabolism." (10077655) |
Regulatory Information |
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Regulatory type | Detail |
phosphorylation; | "Administration of resistin to adipocytes mimicked the effects of GIP on the PKB/LKB1/AMPK/LPL pathway: increasing phosphorylation of PKB, reducing levels of phosphorylated LKB1 and AMPK, and increasing LPL activity." (17890220) |
Gene ontology |
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Gene ontology |
GO:0031225 (C) anchored to membrane [P11152 ]; |
Subcellular localization |
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Localization |
cell membrane [P11152 ]; |
Links |
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SwissProt | |
Entrez Gene |
Copyright 2009, Center for Bioinformatics | |||
Last Modified: 2009-03-24 | |||
Design by Zhao Min |