Center for Bioinformatics
Oxidoreductases | Transferases | Hydrolases | Lyases | Isomerases | Ligases

Basic Information

Enzyme Number

Official Name

lipoprotein lipase

Name from literature

Lipoprotein lipase

Pathway from literature

the hydrolysis of triglyceride-rich lipoproteins and plays an important role in glucose metabolism

Pathway from KEGG

Lipid Metabolism; Glycerolipid metabolism; map00561

Human Diseases; Neurodegenerative Diseases; Alzheimer's disease; map05010

Cellular Processes; Endocrine System; PPAR signaling pathway; map03320


Mouse (10090)

Genome localization

-[669888 ], 8 B3.3|8 33.0 cM[16956 ],


Hydrolyses triacylglycerols in chylomicrons and low-density lipoproteins. Also hydrolyses diacylglycerol.

Rate-limiting Description

"The tissue-specific expression of lipoprotein lipase (LPL) in adipose tissue (AT), skeletal muscle (SM), and cardiac muscle (CM) is rate-limiting for the uptake of triglyceride (TG)-derived free fatty acids and decisive in the regulation of energy balance and lipoprotein metabolism." (10077655)

Regulatory Information

Regulatory type



"Administration of resistin to adipocytes mimicked the effects of GIP on the PKB/LKB1/AMPK/LPL pathway: increasing phosphorylation of PKB, reducing levels of phosphorylated LKB1 and AMPK, and increasing LPL activity." (17890220)

Gene ontology

Gene ontology

GO:0031225 (C) anchored to membrane [P11152 ];
GO:0005886 (C) plasma membrane [P11152 ];
GO:0004465 (F) lipoprotein lipase activity [P11152 ];
GO:0019433 (P) triacylglycerol catabolic process [P11152 ];
GO:0005319 (F) lipid transporter activity [P11152 ];
GO:0042627 (C) chylomicron [P11152 ];
GO:0004806 (F) triacylglycerol lipase activity [P11152 ];
GO:0008201 (F) heparin binding [P11152 ];
GO:0017129 (F) triglyceride binding [P11152 ];

Subcellular localization


cell membrane [P11152 ];




Entrez Gene

16956; 669888

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  Last Modified: 2009-03-24  
  Design by Zhao Min