Center for Bioinformatics
Oxidoreductases | Transferases | Hydrolases | Lyases | Isomerases | Ligases

Basic Information

Enzyme Number

1.9.3.1

Official Name

cytochrome-c oxidase

Name from literature

cytochrome c oxidase

Pathway from literature

oxidative phosphorylation

Pathway from KEGG

Energy Metabolism; Oxidative phosphorylation; map00190

Organisms

Rat (10116)

Genome localization

1q41[25250 ], 6q12[298762 ], 19q12[286962 ], 8q24[252934 ], 1q36[25278 ], 9q21[94194 ], 19q12[29445 ], -[26198 ], -[26195 ], 8q24-q31[29507 ], 3q41[84683 ], Xq31[303393 ], -[26204 ], 7q22[54322 ], 6q32[360229 ],

Comments

A cytochrome of the a type containing copper. The reduction of O2 to water is accompanied by the extrusion of four protons from the intramitochondrial compartment. Several bacteria appear to contain analogous oxidases.

Rate-limiting Description

"COX is the only electron transport chain complex to display isoforms, consistent with its suggested rate-limiting role." (12874793)

Regulatory Information

Upstream transcription factor

81646

Regulatory type

Detail

transcriptional factor;CREB(81646)

"Ang II and EGF synergistically induce COX2 expression via CREB in intestinal epithelial cells." (17559081)

transcriptional factor;

"The role of an E box binding basic helix loop helix protein in the cardiac muscle-specific expression of the rat cytochrome oxidase subunit VIII gene." (8939982)

Gene ontology

Gene ontology

GO:0005751 (C) mitochondrial respiratory chain complex IV [Q64576 ];
GO:0005746 (C) mitochondrial respiratory chain [P05503, A5YN17, A5YMV1, Q06QA9, Q8HIC9, A5YMY5, A4UIA7, A5YN21, A5YN26, Q8SEZ6, A5YMY4, Q95938, Q06QK0, A5YN02 ];
GO:0022900 (P) electron transport chain [P05503 ];
GO:0020037 (F) heme binding [P05503, A5YN17, A5YMV1, Q06QA9, Q8HIC9, A5YMY5, A4UIA7, A5YN21, A5YN26, Q8SEZ6, A5YMY4, Q95938, Q06QK0, A5YN02 ];
GO:0009060 (P) aerobic respiration [P05503, A5YN17, A5YMV1, Q06QA9, Q8HIC9, A5YMY5, A4UIA7, A5YN21, A5YN26, Q8SEZ6, A5YMY4, Q95938, Q06QK0, A5YN02 ];
GO:0005506 (F) iron ion binding [P05503, A5YN17, A5YMV1, Q06QA9, Q8HIC9, A5YMY5, A4UIA7, A5YN21, A5YN26, Q8SEZ6, A5YMY4, Q95938, Q06QK0, A5YN02 ];
GO:0006810 (P) transport [P05503, A5YN17, A5YMV1, Q06QA9, Q8HIC9, A5YMY5, A4UIA7, A5YN21, A5YN26, Q8SEZ6, A5YMY4, Q95938, Q06QK0, A5YN02 ];
GO:0005507 (F) copper ion binding [P05503, A5YN17, A5YMV1, Q06QA9, Q8HIC9, A5YMY5, A4UIA7, A5YN21, A5YN26, Q8SEZ6, A5YMY4, Q95938, Q06QK0, A5YN02 ];
GO:0009055 (F) electron carrier activity [P05503, A5YN17, A5YMV1, Q06QA9, Q8HIC9, A5YMY5, A4UIA7, A5YN21, A5YN26, Q8SEZ6, A5YMY4, Q95938, Q06QK0, A5YN02 ];
GO:0016021 (C) integral to membrane [P05503, P80433, A5YN17, A5YMV1, Q06QA9, Q8HIC9, A5YMY5, A4UIA7, A5YN21, A5YN26, Q8SEZ6, A5YMY4, Q95938, Q06QK0, A5YN02 ];
GO:0004129 (F) cytochrome-c oxidase activity [Q7M0D4, Q64576, Q06QA9, Q8HIC9, A5YN21, Q8SEZ6, A5YMY4, Q95938, Q06QK0, P05503, P80433, A5YMV1, A5YN17, A5YMY5, A5YN26, A4UIA7, A5YN02 ];
GO:0005743 (C) mitochondrial inner membrane [P80433 ];
GO:0055114 (P) oxidation reduction [P80433, A5YN17, A5YMV1, Q06QA9, Q8HIC9, A5YMY5, A4UIA7, A5YN21, A5YN26, Q8SEZ6, A5YMY4, Q95938, Q06QK0, A5YN02 ];

Subcellular localization

Localization

mitochondrion [P05503, P80433, A5YN17, A5YMV1, Q06QA9, Q8HIC9, A5YMY5, A4UIA7, A5YN21, A5YN26, Q8SEZ6, A5YMY4, Q95938, Q06QK0, A5YN02 ];

Links

SwissProt

A4UIA7; A5YMV1; A5YMY4; A5YMY5; A5YN02; A5YN17; A5YN21; A5YN26; P05503; P80433; Q06QA9; Q06QK0; Q64576; Q7M0D4; Q8HIC9; Q8SEZ6; Q95938

Entrez Gene

25250; 25278; 252934; 26195; 26198; 26204; 286962; 29445; 29507; 298762; 303393; 360229; 54322; 84683; 94194



  Copyright 2009, Center for Bioinformatics 
  Last Modified: 2009-03-24  
  Design by Zhao Min