Center for Bioinformatics
Oxidoreductases | Transferases | Hydrolases | Lyases | Isomerases | Ligases

Basic Information

Enzyme Number

1.9.3.1

Official Name

cytochrome-c oxidase

Name from literature

cytochrome c oxidase

Pathway from literature

oxidative phosphorylation

Pathway from KEGG

Energy Metabolism; Oxidative phosphorylation; map00190

Organisms

Mouse (10090)

Genome localization

-[17708 ], 17 E4[20463 ], 19 A[12868 ], 15 B3.3[12864 ], 5 C3.1-C3.2[78174 ], 5 F|5 60.0 cM[12861 ], 1 B[12859 ], 2 H2[84682 ], -[17709 ], 7 F5|7 68.8 cM[12869 ], 9 E1|9 42.0 cM[12866 ], 13 C3[12867 ], 9 B[12858 ], 8 E1|8 64.0 cM[12857 ], 7 B1|7 8.0 cM[12865 ], 7 A1[333182 ], X C3[66142 ], 7 B1|7 10.0 cM[110323 ], 7 F3|7 61.0 cM[12862 ], -[17710 ],

Comments

A cytochrome of the a type containing copper. The reduction of O2 to water is accompanied by the extrusion of four protons from the intramitochondrial compartment. Several bacteria appear to contain analogous oxidases.

Rate-limiting Description

"COX is the only electron transport chain complex to display isoforms, consistent with its suggested rate-limiting role." (12874793)

Regulatory Information

Regulatory type

Detail

phosphorylation;

Q9MD68

phosphorylation;

"Protein kinase A-mediated phosphorylation modulates cytochrome c oxidase function and augments hypoxia and myocardial ischemia-related injury" (16303765)

phosphorylation;

"Tumor necrosis factor alpha inhibits oxidative phosphorylation through tyrosine phosphorylation at subunit I of cytochrome c oxidase" (18534980)

transcriptional factor;Tumor necrosis factor alpha(21926)

"Tumor necrosis factor alpha inhibits oxidative phosphorylation through tyrosine phosphorylation at subunit I of cytochrome c oxidase" (18534980)

Gene ontology

Gene ontology

GO:0005746 (C) mitochondrial respiratory chain [Q3UR21, Q3TRT0, A5YMZ6, Q3UQ58, A5YMZ7, A5YMZ9, Q5BP84, Q3TML7, A5YMZ4, Q5BP85, Q70YN3, Q3UTW3, A5YMZ2, Q5BP88, A5YN00, Q9MD68, A5YMZ3, A5YMU1, A5YMZ8, P00397, Q35042, A5YMZ5 ];
GO:0022900 (P) electron transport chain [P00397 ];
GO:0020037 (F) heme binding [Q3UR21, Q3TRT0, A5YMZ6, Q3UQ58, A5YMZ7, A5YMZ9, Q5BP84, Q3TML7, A5YMZ4, Q5BP85, Q70YN3, Q3UTW3, A5YMZ2, Q5BP88, A5YN00, Q9MD68, A5YMZ3, A5YMU1, A5YMZ8, P00397, Q35042, A5YMZ5 ];
GO:0009060 (P) aerobic respiration [Q3UR21, Q3TRT0, A5YMZ6, Q3UQ58, A5YMZ7, A5YMZ9, Q5BP84, Q3TML7, A5YMZ4, Q5BP85, Q70YN3, Q3UTW3, A5YMZ2, Q5BP88, A5YN00, Q9MD68, A5YMZ3, A5YMU1, A5YMZ8, P00397, Q35042, A5YMZ5 ];
GO:0005506 (F) iron ion binding [Q3UR21, Q3TRT0, A5YMZ6, Q3UQ58, A5YMZ7, A5YMZ9, Q5BP84, Q3TML7, A5YMZ4, Q5BP85, Q70YN3, Q3UTW3, A5YMZ2, Q5BP88, A5YN00, Q9MD68, A5YMZ3, A5YMU1, A5YMZ8, P00397, Q35042, A5YMZ5 ];
GO:0006810 (P) transport [Q3UR21, Q3TRT0, A5YMZ6, Q3UQ58, A5YMZ7, A5YMZ9, Q5BP84, Q3TML7, A5YMZ4, Q5BP85, Q70YN3, Q3UTW3, A5YMZ2, Q5BP88, A5YN00, Q9MD68, A5YMZ3, A5YMU1, A5YMZ8, P00397, Q35042, A5YMZ5 ];
GO:0005507 (F) copper ion binding [Q3UR21, Q3TRT0, A5YMZ6, Q3UQ58, A5YMZ7, A5YMZ9, Q5BP84, Q3TML7, A5YMZ4, Q5BP85, Q70YN3, Q3UTW3, A5YMZ2, Q5BP88, A5YN00, Q9MD68, A5YMZ3, A5YMU1, A5YMZ8, P00397, Q35042, A5YMZ5 ];
GO:0009055 (F) electron carrier activity [Q3UR21, Q3TRT0, A5YMZ6, Q3UQ58, A5YMZ7, A5YMZ9, Q5BP84, Q3TML7, A5YMZ4, Q5BP85, Q70YN3, Q3UTW3, A5YMZ2, Q5BP88, A5YN00, Q9MD68, A5YMZ3, A5YMU1, A5YMZ8, P00397, Q35042, A5YMZ5 ];
GO:0016021 (C) integral to membrane [Q3UR21, Q3TRT0, A5YMZ6, Q3UQ58, A5YMZ7, A5YMZ9, Q5BP84, Q3TML7, A5YMZ4, Q5BP85, Q70YN3, Q3UTW3, A5YMZ2, Q5BP88, A5YN00, Q9MD68, A5YMZ3, A5YMU1, A5YMZ8, P00397, Q35042, A5YMZ5 ];
GO:0004129 (F) cytochrome-c oxidase activity [Q3UR21, Q3TRT0, A5YMZ6, Q3UQ58, A5YMZ7, A5YMZ9, Q5BP84, Q3TML7, A5YMZ4, Q5BP85, Q70YN3, Q3UTW3, A5YMZ2, Q5BP88, A5YN00, Q9MD68, A5YMZ3, A5YMU1, A5YMZ8, P00397, Q35042, A5YMZ5 ];
GO:0055114 (P) oxidation reduction [Q3UR21, Q3TRT0, A5YMZ6, Q3UQ58, A5YMZ7, A5YMZ9, Q5BP84, Q3TML7, A5YMZ4, Q5BP85, Q70YN3, Q3UTW3, A5YMZ2, Q5BP88, A5YN00, Q9MD68, A5YMZ3, A5YMU1, A5YMZ8, Q35042, A5YMZ5 ];

Subcellular localization

Localization

mitochondrion [Q3UR21, Q3TRT0, A5YMZ6, Q3UQ58, A5YMZ7, A5YMZ9, Q5BP84, Q3TML7, A5YMZ4, Q5BP85, Q70YN3, Q3UTW3, A5YMZ2, Q5BP88, A5YN00, Q9MD68, A5YMZ3, A5YMU1, A5YMZ8, P00397, Q35042, A5YMZ5 ];

Links

SwissProt

A5YMU1; A5YMZ2; A5YMZ3; A5YMZ4; A5YMZ5; A5YMZ6; A5YMZ7; A5YMZ8; A5YMZ9; A5YN00; P00397; Q35042; Q3TML7; Q3TRT0; Q3UQ58; Q3UR21; Q3UTW3; Q5BP84; Q5BP85; Q5BP88; Q70YN3; Q9MD68

Entrez Gene

110323; 12857; 12858; 12859; 12861; 12862; 12864; 12865; 12866; 12867; 12868; 12869; 17708; 17709; 17710; 20463; 333182; 66142; 78174; 84682



  Copyright 2009, Center for Bioinformatics 
  Last Modified: 2009-03-24  
  Design by Zhao Min