Center for Bioinformatics
Oxidoreductases | Transferases | Hydrolases | Lyases | Isomerases | Ligases

Basic Information

Enzyme Number

2.7.7.14

Official Name

ethanolamine-phosphate cytidylyltransferase

Name from literature

phosphoethanolamine cytidylyltransferase

Pathway from literature

phosphatidylethanolamine synthesis

Pathway from KEGG

Metabolism of Other Amino Acids; Aminophosphonate metabolism; map00440

Lipid Metabolism; Glycerophospholipid metabolism; map00564

Organisms

Rat (10116)

Genome localization

10q32.3[89841 ],

Rate-limiting Description

"An analysis of the available data on the cytidine pathway for the synthesis of phosphatidylcholine and phosphatidylethanolamine, by the logic derived from the theoretical principles of metabolic regulation, shows that the first two reactions catalysed by choline (ethanolamine) kinase and phosphocholine (phosphoethanolamine) cytidylyltransferase are rate-limiting, whereas the phosphocholine (phosphoethanolamine) transferase step is near equilibrium in rat liver.." (603639)

"This flux change was used to test the possible regulatory roles of ethanolamine kinase and of phosphoethanolamine cytidylyltransferase, which are rate-limiting enzymes of the cytidine pathway for the synthesis of phosphatidylethanolamine ." (Infante (1977) Biochem)

"The activities of the rate-limiting enzymes in the de novo synthesis of PC and PE, CTP:phosphocholine cytidylyltransferase (CT), and CTP:phosphoethanolamine cytidylyltransferase (ET), respectively, were measured in the retinas excised at 5:00, 9:00, 13:00, and 17:00 h from rats adapted to a 24-h cycle with lights on from 7:00 to 19:00 h." (11097182)

Gene ontology

Gene ontology

GO:0004306 (F) ethanolamine-phosphate cytidylyltransferase... [O88637 ];
GO:0008654 (P) phospholipid biosynthetic process [O88637 ];

Links

SwissProt

O88637

Entrez Gene

89841



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  Last Modified: 2009-03-24  
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