Center for Bioinformatics
Oxidoreductases | Transferases | Hydrolases | Lyases | Isomerases | Ligases

Basic Information

Enzyme Number

2.4.2.14

Official Name

amidophosphoribosyltransferase

Name from literature

phosphoribosyl pyrophosphate amidotransferase

Pathway from literature

the purine de novo pathway

Pathway from KEGG

Amino Acid Metabolism; Glutamate metabolism; map00251

Nucleotide Metabolism; Purine metabolism; map00230

Organisms

Rat (10116)

Genome localization

14p11[117544 ],

Rate-limiting Description

"The reciprocal plots for 5-phosphoribosyl-1-pyrophosphate (PRPP) of liver and hepatoma enzymes gave apparent KmS of 2 microM for adenine phosphoribosyltransferase and 4 microM for HGPRT, showing two orders of magnitude higher affinities for PRPP than that of the rate-limiting enzyme of de novo purine synthesis, amidophosphoribosyltransferase (EC 2.4.2.14) (Km = 400 to 900 microM)." (6327016)

Gene ontology

Gene ontology

GO:0000287 (F) magnesium ion binding [P35433 ];
GO:0006164 (P) purine nucleotide biosynthetic process [P35433 ];
GO:0051539 (F) 4 iron, 4 sulfur cluster binding [P35433 ];
GO:0005506 (F) iron ion binding [P35433 ];
GO:0006541 (P) glutamine metabolic process [P35433 ];
GO:0004044 (F) amidophosphoribosyltransferase activity [P35433 ];
GO:0009116 (P) nucleoside metabolic process [P35433 ];
GO:0009113 (P) purine base biosynthetic process [P35433 ];

Links

SwissProt

P35433

Entrez Gene

117544



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  Last Modified: 2009-03-24  
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