Center for Bioinformatics
Oxidoreductases | Transferases | Hydrolases | Lyases | Isomerases | Ligases

Basic Information

Enzyme Number

2.4.2.14

Official Name

amidophosphoribosyltransferase

Name from literature

phosphoribosyl pyrophosphate amidotransferase

Pathway from literature

the purine de novo pathway

Pathway from KEGG

Amino Acid Metabolism; Glutamate metabolism; map00251

Nucleotide Metabolism; Purine metabolism; map00230

Organisms

Mouse (10090)

Genome localization

5 C3.3[231327 ],

Rate-limiting Description

"The reciprocal plots for 5-phosphoribosyl-1-pyrophosphate (PRPP) of liver and hepatoma enzymes gave apparent KmS of 2 microM for adenine phosphoribosyltransferase and 4 microM for HGPRT, showing two orders of magnitude higher affinities for PRPP than that of the rate-limiting enzyme of de novo purine synthesis, amidophosphoribosyltransferase (EC 2.4.2.14) (Km = 400 to 900 microM)." (6327016)

Links

Entrez Gene

231327



  Copyright 2009, Center for Bioinformatics 
  Last Modified: 2009-03-24  
  Design by Zhao Min