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Oxidoreductases | Transferases | Hydrolases | Lyases | Isomerases | Ligases |
Basic Information |
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Enzyme Number | 1.14.19.1 |
Official Name | stearoyl-CoA 9-desaturase |
Name from literature | Stearoyl-CoA desaturase |
Pathway from literature | monounsaturated fatty acid synthesis,oleic acid synthesis, |
Pathway from KEGG |
Cellular Processes; Endocrine System; PPAR signaling pathway; map03320 |
Lipid Metabolism; Biosynthesis of unsaturated fatty acids; map01040 | |
Organisms | Rat (10116) |
Genome localization | |
Comments | An iron protein. The rat liver enzyme is an enzyme system involving cytochrome b5 and EC 1.6.2.2, cytochrome-b5 reductase. The ferricytochrome b5 produced is reduced by NADH and cytochrome-b5 reductase (EC 1.6.2.2). |
Rate-limiting Description | "A key enzyme involved in this process is the membrane-bound stearoyl-CoA desaturase (SCD) which is the rate-limiting enzyme in the cellular synthesis of monounsaturated fatty acids from saturated fatty acids." (10484602) |
| "Stearoyl-CoA desaturase (SCD) is a key rate-limiting enzyme in the synthesis of unsaturated fatty acids by insertion of a cis-double bond in the Delta9 position of fatty acid substrates." (10581155) |
Regulatory Information |
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Upstream transcription factor | |
Regulatory type | Detail |
transcriptional factor;PPARalpha(25747) | "PPARalpha is required to mediate the response of Scd-1 and Fas gene expression to insulin and that this is normally achieved directly by activation of LXRalpha." (18079124) |
Gene ontology |
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Gene ontology |
GO:0016021 (C) integral to membrane [Q6P7B9, P07308 ]; |
Subcellular localization |
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Localization | |
Links |
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SwissProt | |
Entrez Gene |
Copyright 2009, Center for Bioinformatics | |||
Last Modified: 2009-03-24 | |||
Design by Zhao Min |