Center for Bioinformatics
Oxidoreductases | Transferases | Hydrolases | Lyases | Isomerases | Ligases

Basic Information

Enzyme Number

1.14.19.1

Official Name

stearoyl-CoA 9-desaturase

Name from literature

Stearoyl-CoA desaturase

Pathway from literature

monounsaturated fatty acid synthesis,oleic acid synthesis,

Pathway from KEGG

Cellular Processes; Endocrine System; PPAR signaling pathway; map03320

Lipid Metabolism; Biosynthesis of unsaturated fatty acids; map01040

Organisms

Mouse (10090)

Genome localization

19 C3|19 43.0 cM[20250 ], 19 C3|19 43.0 cM[20249 ], 19 C3[30049 ],

Comments

An iron protein. The rat liver enzyme is an enzyme system involving cytochrome b5 and EC 1.6.2.2, cytochrome-b5 reductase. The ferricytochrome b5 produced is reduced by NADH and cytochrome-b5 reductase (EC 1.6.2.2).

Rate-limiting Description

"A key enzyme involved in this process is the membrane-bound stearoyl-CoA desaturase (SCD) which is the rate-limiting enzyme in the cellular synthesis of monounsaturated fatty acids from saturated fatty acids." (10484602)

"Stearoyl-CoA desaturase (SCD) is a key rate-limiting enzyme in the synthesis of unsaturated fatty acids by insertion of a cis-double bond in the Delta9 position of fatty acid substrates." (10581155)

Regulatory Information

Upstream transcription factor

20787;19013

Regulatory type

Detail

phosphorylation;

P13516

transcriptional factor;SREBP-1c(20787)

"oleate produced by stearoyl-CoA desaturase 1 is necessary for fructose-mediated induction of lipogenic gene expression through SREBP-1c-dependent and -independent mechanisms." (15066988)

transcriptional factor;PPARalpha(19013)

"PPARalpha is required to mediate the response of Scd-1 and Fas gene expression to insulin and that this is normally achieved directly by activation of LXRalpha." (18079124)

Gene ontology

Gene ontology

GO:0016021 (C) integral to membrane [P13516, P13011 ];
GO:0004768 (F) stearoyl-CoA 9-desaturase activity [P13516, P13011 ];
GO:0055114 (P) oxidation reduction [P13516, P13011 ];
GO:0005506 (F) iron ion binding [P13516, P13011 ];
GO:0006633 (P) fatty acid biosynthetic process [P13516, P13011 ];
GO:0005789 (C) endoplasmic reticulum membrane [P13516, P13011 ];

Subcellular localization

Localization

endoplasmic reticulum [P13516, P13011 ];

Links

SwissProt

P13011; P13516

Entrez Gene

20249; 20250; 30049



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  Last Modified: 2009-03-24  
  Design by Zhao Min