2.3.1.26

sterol O-acyltransferase

acyl coA:cholesterol acyltransferase

cholesterol esterification

Mouse (10090)

1 G3|1 81.6 cM[20652 ], 15 F3|15 61.7 cM[223920 ],

The animal enzyme is highly specific for transfer of acyl groups with a single cis double bond that is nine carbon atoms distant from the carboxy group.

"Coinfection of mice with adenoviruses expressing human LCAT and the helix 6P mutant dramatically increased plasma HDL and apoA-I levels and converted the discoidal into spherical HDL, indicating that the LCAT activity was rate-limiting for the biogenesis of HDL." (16245952)

GO:0005624 (C) membrane fraction [O88908 ];
GO:0008203 (P) cholesterol metabolic process [O88908, Q61263 ];
GO:0034737 (F) ergosterol O-acyltransferase activity [O88908, Q61263 ];
GO:0034736 (F) cholesterol O-acyltransferase activity [O88908, Q61263 ];
GO:0005789 (C) endoplasmic reticulum membrane [O88908, Q61263 ];
GO:0034738 (F) lanosterol O-acyltransferase activity [O88908, Q61263 ];
GO:0016021 (C) integral to membrane [O88908, Q61263 ];
GO:0005792 (C) microsome [Q61263 ];

endoplasmic reticulum [O88908, Q61263 ];

O88908; Q61263

20652; 223920