Center for Bioinformatics
Oxidoreductases | Transferases | Hydrolases | Lyases | Isomerases | Ligases

Basic Information

Enzyme Number

2.3.1.26

Official Name

sterol O-acyltransferase

Name from literature

acyl coA:cholesterol acyltransferase

Pathway from literature

cholesterol esterification

Pathway from KEGG

Lipid Metabolism; Bile acid biosynthesis; map00120

Organisms

Mouse (10090)

Genome localization

1 G3|1 81.6 cM[20652 ], 15 F3|15 61.7 cM[223920 ],

Comments

The animal enzyme is highly specific for transfer of acyl groups with a single cis double bond that is nine carbon atoms distant from the carboxy group.

Rate-limiting Description

"Coinfection of mice with adenoviruses expressing human LCAT and the helix 6P mutant dramatically increased plasma HDL and apoA-I levels and converted the discoidal into spherical HDL, indicating that the LCAT activity was rate-limiting for the biogenesis of HDL." (16245952)

Gene ontology

Gene ontology

GO:0005624 (C) membrane fraction [O88908 ];
GO:0008203 (P) cholesterol metabolic process [O88908, Q61263 ];
GO:0034737 (F) ergosterol O-acyltransferase activity [O88908, Q61263 ];
GO:0034736 (F) cholesterol O-acyltransferase activity [O88908, Q61263 ];
GO:0005789 (C) endoplasmic reticulum membrane [O88908, Q61263 ];
GO:0034738 (F) lanosterol O-acyltransferase activity [O88908, Q61263 ];
GO:0016021 (C) integral to membrane [O88908, Q61263 ];
GO:0005792 (C) microsome [Q61263 ];

Subcellular localization

Localization

endoplasmic reticulum [O88908, Q61263 ];

Links

SwissProt

O88908; Q61263

Entrez Gene

20652; 223920



  Copyright 2009, Center for Bioinformatics 
  Last Modified: 2009-03-24  
  Design by Zhao Min