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Oxidoreductases | Transferases | Hydrolases | Lyases | Isomerases | Ligases |
Basic Information |
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Enzyme Number | 2.3.1.26 |
Official Name | sterol O-acyltransferase |
Name from literature | acyl coA:cholesterol acyltransferase |
Pathway from literature | cholesterol esterification |
Pathway from KEGG |
Lipid Metabolism; Bile acid biosynthesis; map00120 |
Organisms | Mouse (10090) |
Genome localization | |
Comments | The animal enzyme is highly specific for transfer of acyl groups with a single cis double bond that is nine carbon atoms distant from the carboxy group. |
Rate-limiting Description | "Coinfection of mice with adenoviruses expressing human LCAT and the helix 6P mutant dramatically increased plasma HDL and apoA-I levels and converted the discoidal into spherical HDL, indicating that the LCAT activity was rate-limiting for the biogenesis of HDL." (16245952) |
Gene ontology |
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Gene ontology |
GO:0005624 (C) membrane fraction [O88908 ]; |
Subcellular localization |
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Localization | |
Links |
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SwissProt | |
Entrez Gene |
Copyright 2009, Center for Bioinformatics | |||
Last Modified: 2009-03-24 | |||
Design by Zhao Min |