Center for Bioinformatics
Oxidoreductases | Transferases | Hydrolases | Lyases | Isomerases | Ligases

Basic Information

Enzyme Number

1.1.1.145

Official Name

3beta-hydroxy-Delta5-steroid dehydrogenase

Name from literature

hydroxy delta steroid dehydrogenase

Pathway from literature

the sex steroid hormone biosynthesis pathway

Pathway from KEGG

Lipid Metabolism; Androgen and estrogen metabolism; map00150

Lipid Metabolism; C21-Steroid hormone metabolism; map00140

Organisms

Rat (10116)

Genome localization

2q34[24470 ], 2q34[29632 ],

Comments

Acts on 3beta-hydroxyandrost-5-en-17-one to form androst-4-ene-3,17-dione and on 3beta-hydroxypregn-5-en-20-one to form progesterone.

Rate-limiting Description

"Hydroxyflutamide a specific androgen receptor (AR) antagonist, and cyproterone acetate or trilostane, both inhibitors of 3 beta-hydroxysteroid dehydrogenase/delta 4,5 isomerase, the rate-limiting enzyme for the conversion of DHEA to sex steroids, did not affect the ability of DHEA to downregulate GnRH gene expression." (12782399)

"We investigated the first step of the sex steroid hormone biosynthesis pathway by assaying the activities of 3 beta-hydroxy-delta 5-steroid dehydrogenase, the rate-limiting enzyme in this pathway." (12441193)

Regulatory Information

Upstream transcription factor

313929;54244;83516

Regulatory type

Detail

transcriptional factor;"PGC-1alpha(83516),CBP(54244)/SRC-1(313929)"

"ERalpha interaction with transcription coregulators, histone acetylases (CBP/SRC-1), and PGC-1alpha is crucial to FSH and TGFbeta1-up-regulated expression of Hsd3b and Cyp11a1, and, thus, progesterone production in rat ovarian granulosa cells." (18511507)

Gene ontology

Gene ontology

GO:0031966 (C) mitochondrial membrane [P22072, P22071, Q62878 ];
GO:0003854 (F) 3-beta-hydroxy-delta5-steroid dehydrogenase... [P22072, P22071, Q62878 ];
GO:0016021 (C) integral to membrane [P22072, P22071, Q62878 ];
GO:0006700 (P) C21-steroid hormone biosynthetic process [P22072, P22071, Q62878 ];
GO:0005488 (F) binding [P22072, P22071, Q62878 ];
GO:0055114 (P) oxidation reduction [P22072, P22071, Q62878 ];
GO:0005789 (C) endoplasmic reticulum membrane [P22072, P22071, Q62878 ];
GO:0004769 (F) steroid delta-isomerase activity [P22072, P22071, Q62878 ];

Subcellular localization

Localization

mitochondrion [P22072, P22071, Q62878 ];

endoplasmic reticulum [P22072, P22071, Q62878 ];

Links

Entrez Gene

24470; 29632



  Copyright 2009, Center for Bioinformatics 
  Last Modified: 2009-03-24  
  Design by Zhao Min