Center for Bioinformatics
Oxidoreductases | Transferases | Hydrolases | Lyases | Isomerases | Ligases

Basic Information

Enzyme Number

3.1.3.5

Official Name

5'-nucleotidase

Name from literature

5'-nucleotidase

Pathway from literature

transformation of AMP to adenosine

Pathway from KEGG

Metabolism of Cofactors and Vitamins; Nicotinate and nicotinamide metabolism; map00760

Nucleotide Metabolism; Purine metabolism; map00230

Nucleotide Metabolism; Pyrimidine metabolism; map00240

Organisms

Mouse (10090)

Genome localization

11 E[50773 ], 4 D2.2[230718 ], 6 B3[107569 ], 19 D2[76952 ], 12 A2[70881 ], 9 E3.2[23959 ], 11 B[103850 ],

Comments

Wide specificity for 5'-nucleotides.

Rate-limiting Description

"Because ectoapyrase (CD39) and ecto-5'-nucleotidase (CD73) are rate limiting for extracellular adenosine generation, we examined their contribution to ALI." (17548651)

"Because ecto-5'-nucleotidase (CD73) is rate limiting for extracellular adenosine generation, this study examined the contribution of CD73-dependent adenosine production to ischemic preconditioning (IP) of the kidneys. ." (17267736)

"The cytosolic deoxycytidine kinase (dCK; EC 2.7.1.74) and thymidine kinase (TK1; EC 2.7.1.21), the mitochondrial thymidine kinase (TK2) and deoxyguanosine kinase (dGK; EC 2.7.1.113) as well as 5'-deoxynucleotidases (5'-dNT; EC 3.1.3.5) are enzymes that control rate-limiting steps in formation of intracellular and intra-mitochondrial nucleotides." (17493587)

Regulatory Information

Regulatory type

Detail

phosphorylation;

Q3V1L4

phosphorylation;

Q91YE9

phosphorylation;

Q3V1L4:from_uniprot:502_Phosphoserine

phosphorylation;

Q3V1L4:from_uniprot:527_Phosphoserine

Gene ontology

Gene ontology

GO:0008270 (F) zinc ion binding [Q61503 ];
GO:0000287 (F) magnesium ion binding [Q9D020, Q3UFY7, A3KFX0, Q3V1L4, Q91YE9 ];
GO:0005783 (C) endoplasmic reticulum [Q9D020 ];
GO:0008253 (F) 5'-nucleotidase activity [Q9D020, Q3UFY7, Q61503, A3KFX0, Q3V1L4, Q91YE9 ];
GO:0031225 (C) anchored to membrane [Q61503 ];
GO:0000166 (F) nucleotide binding [Q9D020, Q3UFY7, Q61503, A3KFX0, Q3V1L4, Q91YE9 ];
GO:0005886 (C) plasma membrane [Q61503 ];
GO:0005829 (C) cytosol [Q91YE9 ];
GO:0005737 (C) cytoplasm [Q3UFY7, A3KFX0, Q3V1L4 ];
GO:0009166 (P) nucleotide catabolic process [Q61503 ];
GO:0009117 (P) nucleotide metabolic process [Q9D020, Q3UFY7, A3KFX0, Q3V1L4, Q91YE9 ];
GO:0009116 (P) nucleoside metabolic process [Q91YE9 ];
GO:0016740 (F) transferase activity [Q9D020, Q3UFY7 ];

Subcellular localization

Localization

cell membrane [Q61503 ];

cytoplasm [Q9D020, Q3UFY7, A3KFX0, Q3V1L4, Q91YE9 ];

Links

SwissProt

A3KFX0; Q3UFY7; Q3V1L4; Q61503; Q91YE9; Q9D020

Entrez Gene

103850; 107569; 230718; 23959; 50773; 70881; 76952



  Copyright 2009, Center for Bioinformatics 
  Last Modified: 2009-03-24  
  Design by Zhao Min