Center for Bioinformatics
Oxidoreductases | Transferases | Hydrolases | Lyases | Isomerases | Ligases

Basic Information

Enzyme Number

2.6.1.5

Official Name

tyrosine transaminase

Name from literature

tyrosine aminotransferase

Pathway from literature

catabolic pathway of tyrosine

Pathway from KEGG

Amino Acid Metabolism; Phenylalanine, tyrosine and tryptophan biosynthesis; map00400

Amino Acid Metabolism; Phenylalanine metabolism; map00360

Biosynthesis of Secondary Metabolites; Alkaloid biosynthesis I; map00950

Amino Acid Metabolism; Methionine metabolism; map00271

Biosynthesis of Secondary Metabolites; Novobiocin biosynthesis; map00401

Amino Acid Metabolism; Tyrosine metabolism; map00350

Organisms

Mouse (10090)

Genome localization

8 D3[234724 ],

Comments

A pyridoxal-phosphate protein. L-Phenylalanine can act instead of L-tyrosine. The mitochondrial enzyme may be identical with EC 2.6.1.1 (aspartate transaminase). The three isoenzymic forms are interconverted by EC 3.4.22.32 (stem bromelain) and EC 3.4.22.33 (fruit bromelain). The enzyme can also catalyse the final step in the methionine-salvage pathway of Klebsiella pneumoniae [8].

Rate-limiting Description

"In addition, biologically active NRF-1 sites are found in genes encoding the eukaryotic translation initiation factor 2 alpha-subunit and tyrosine aminotransferase, both of which participate in the rate-limiting step of their respective pathways of protein biosynthesis and tyrosine catabolism." (1348057)

Regulatory Information

Upstream transcription factor

15378

Regulatory type

Detail

transcriptional factor;Hnf4a(15378),hepatocyte nuclear factor 3 family

"n the two enhancers mediating hormone induction of TAT gene activity we find the hormone response elements in combination with binding sites for constitutive liver-enriched transcription factors: proteins of the hepatocyte nuclear factor 3 family bind in the vicinity of the glucocorticoid response element located 2.5 kb upstream of the transcription start site, while hepatocyte nuclear factor 4 interacts with an essential element in the cAMP-responsive enhancer at -3.6 kb. " (8100067)

Gene ontology

Gene ontology

GO:0030170 (F) pyridoxal phosphate binding [Q8QZR1 ];
GO:0004838 (F) tyrosine transaminase activity [Q8QZR1 ];
GO:0009058 (P) biosynthetic process [Q8QZR1 ];
GO:0005739 (C) mitochondrion [Q8QZR1 ];
GO:0016847 (F) 1-aminocyclopropane-1-carboxylate synthase ... [Q8QZR1 ];
GO:0006559 (P) L-phenylalanine catabolic process [Q8QZR1 ];
GO:0006572 (P) tyrosine catabolic process [Q8QZR1 ];

Links

SwissProt

Q8QZR1

Entrez Gene

234724



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  Last Modified: 2009-03-24  
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