Center for Bioinformatics
Oxidoreductases | Transferases | Hydrolases | Lyases | Isomerases | Ligases

Basic Information

Enzyme Number

1.14.14.1

Official Name

unspecific monooxygenase

Name from literature

Aromatase

Pathway from literature

estrogen biosynthesis

Pathway from KEGG

Lipid Metabolism; Androgen and estrogen metabolism; map00150

Xenobiotics Biodegradation and Metabolism; gamma-Hexachlorocyclohexane degradation; map00361

Xenobiotics Biodegradation and Metabolism; Metabolism of xenobiotics by cytochrome P450; map00980

Metabolism of Cofactors and Vitamins; Retinol metabolism; map00830

Lipid Metabolism; Fatty acid metabolism; map00071

Lipid Metabolism; Linoleic acid metabolism; map00591

Lipid Metabolism; Arachidonic acid metabolism; map00590

Amino Acid Metabolism; Tryptophan metabolism; map00380

Xenobiotics Biodegradation and Metabolism; Drug metabolism - cytochrome P450; map00982

Xenobiotics Biodegradation and Metabolism; Drug metabolism - other enzymes; map00983

Biosynthesis of Secondary Metabolites; Caffeine metabolism; map00232

Organisms

Mouse (10090)

Genome localization

5 G3|5 85.0 cM[56388 ], 7 A3|7 6.5 cM[13088 ], 4 C5[74519 ], 19 C3[404195 ], 19 C3[72082 ], 9 B|9 31.0 cM[13076 ], 7 F5|7 68.4 cM[13106 ], 9 A5.3|9 31.0 cM[13075 ], 15 E1|15 47.2 cM[13101 ], 9 B|9 31.0 cM[13077 ], 7 A3|7 6.5 cM[13089 ], 7 A3|7 7.3 cM[13090 ], 17 E3[13078 ], 7 A3|7 6.5 cM[13086 ], 7 A3|7 6.5 cM[13087 ], 4 D1[81906 ], -[56448 ], 19 C3[72303 ], 15 E1|15 47.2 cM[13105 ], 5 G2|5 78.0 cM[13113 ], 19 C3[226105 ], 15 E1[76279 ], 19 C3[13099 ], 5 G2|5 85.0 cM[53973 ], 19 C3[13096 ], 7 A3[74134 ], 7 A3[13085 ], 5 G2|5 85.0 cM[13114 ], 19 C3[69888 ], 19 C3[13097 ], 4 C5|4 46.5 cM[13109 ], 7 A3|7 6.5 cM[13094 ], 19 C3[107141 ], 5 G2|5 85.0 cM[13112 ], 19 C3[226143 ], 4 C5|4 46.5 cM[13110 ], 5 G2|5 85.0 cM[337924 ], 7 A3[13107 ], 19 27.0 cM[13095 ], 19 C3[13098 ], 4 D1|4 49.5 cM[13120 ],

Comments

A group of heme-thiolate proteins (P-450), acting on a wide range of substrates including many xenobiotics, steroids, fatty acids, vitamins and prostaglandins; reactions catalysed include hydroxylation, epoxidation, N-oxidation, sulfooxidation, N-, S- and O-dealkylations, desulfation, deamination, and reduction of azo, nitro and N-oxide groups. Together with EC 1.6.2.4, NADPH---hemoprotein reductase, it forms a system in which two reducing equivalents are supplied by NADPH. Some of the reactions attributed to EC 1.14.15.3, alkane 1-monooxygenase, belong here.

Rate-limiting Description

"Thus it is important to understanding how P450s participate in the carcinogenesis process and to determine if they are indeed the rate limiting and critical interface between the chemical and its biological activity." (10503904)

Regulatory Information

Upstream transcription factor

19017;15378;18024;21405

Regulatory type

Detail

phosphorylation;

P00184

phosphorylation;

P28649

phosphorylation;

Q05421

phosphorylation;

Q64459

phosphorylation;

Q9D816

phosphorylation;

O55071:from_uniprot:129_Phosphoserine; by PKA

phosphorylation;

P00184:from_uniprot:364_Phosphoserine

phosphorylation;

P11714:from_uniprot:138_Phosphoserine

phosphorylation;

P12790:from_uniprot:128_Phosphoserine; by PKA

phosphorylation;

P12791:from_uniprot:128_Phosphoserine; by PKA

phosphorylation;

P56593:from_uniprot:130_Phosphoserine

phosphorylation;

Q05421:from_uniprot:129_Phosphoserine

phosphorylation;

Q8CIM7:from_uniprot:138_Phosphoserine

transcriptional factor;PGC-1alpha(19017)

"Coactivator PGC-1alpha regulates the fasting inducible xenobiotic-metabolizing enzyme CYP2A5 in mouse primary hepatocytes." (18602936)

transcriptional factor;Nrf2(18024)

"Nrf2, through up-regulation of glutamate-cysteine ligase and increase of GSH levels, protects against CYP2E1-dependent AA toxicity" (16551616)

transcriptional factor;HNF-1alpha(21405)

"Transcription activator of HNF-1alpha acts periodically and the negative limbs of molecular clocks periodically inhibit CYP2E1 transcription, resulting in the 24-hour rhythm of its mRNA expression." (18537186)

transcriptional factor;Hnf4a(15378)

"Transcriptional regulation by HNF-4 of the steroid 15alpha-hydroxylase P450 (Cyp2a-4) gene in mouse liver." (9408084)

transcriptional factor;HNF4(15378),HNF1(21405)

"Regulation of Cyp2a5 transcription in mouse primary hepatocytes: roles of hepatocyte nuclear factor 4 and nuclear factor I." (15115437)

Gene ontology

Gene ontology

GO:0010468 (P) regulation of gene expression [P00186 ];
GO:0018894 (P) dibenzo-p-dioxin metabolic process [P00186 ];
GO:0016020 (C) membrane [P28649 ];
GO:0020037 (F) heme binding [Q9JMA7, Q64459, P11714, Q64429, O09158, Q64481, P15392, P56657, Q6XVG2, P24456, Q64458, P56593, Q91WL5, O54750, Q91X77, P56654, P56656, Q91W64, P24457, Q05421, Q64462, Q8CIM7, Q9D816, Q9DBX6, P00186, P12790, P28649, O55071, P20852, P56655, Q9CX98, Q64464, O54749, P00184, P12791 ];
GO:0030324 (P) lung development [P00186 ];
GO:0050665 (P) hydrogen peroxide biosynthetic process [P00186, P00184 ];
GO:0016021 (C) integral to membrane [Q9CX98 ];
GO:0045333 (P) cellular respiration [P00186 ];
GO:0009055 (F) electron carrier activity [Q9JMA7, Q64459, P11714, Q64429, O09158, Q64481, P15392, P56657, Q6XVG2, P24456, Q64458, P56593, Q91WL5, O54750, Q91X77, P56654, P56656, Q91W64, P24457, Q05421, Q64462, Q8CIM7, Q9D816, Q9DBX6, P00186, P12790, P28649, O55071, P20852, P56655, Q9CX98, Q64464, O54749, P00184, P12791 ];
GO:0050381 (F) unspecific monooxygenase activity [Q9JMA7, Q64459, P11714, Q64429, O09158, Q64481, P15392, P56657, Q6XVG2, P24456, Q64458, P56593, Q91WL5, O54750, Q91X77, P56654, P56656, Q91W64, P24457, Q05421, Q64462, Q8CIM7, Q9D816, Q9DBX6, P00186, P12790, P28649, O55071, P20852, P56655, Q9CX98, Q64464, O54749, P00184, P12791 ];
GO:0009404 (P) toxin metabolic process [P00186, Q64429, P00184 ];
GO:0006778 (P) porphyrin metabolic process [P00186 ];
GO:0005506 (F) iron ion binding [Q9JMA7, Q64459, P11714, Q64429, O09158, Q64481, P15392, P56657, Q6XVG2, P24456, Q64458, P56593, Q91WL5, O54750, Q91X77, P56654, P56656, Q91W64, P24457, Q05421, Q64462, Q8CIM7, Q9D816, Q9DBX6, P00186, P12790, P28649, O55071, P20852, P56655, Q9CX98, Q64464, O54749, P00184, P12791 ];
GO:0005789 (C) endoplasmic reticulum membrane [Q9JMA7, Q64459, P11714, Q64429, O09158, Q64481, P15392, P56657, Q6XVG2, P24456, Q64458, P56593, Q91WL5, O54750, Q91X77, P56654, P56656, Q91W64, P24457, Q05421, Q64462, Q8CIM7, Q9D816, Q9DBX6, P00186, P12790, O55071, P20852, P56655, Q9CX98, Q64464, O54749, P00184, P12791 ];
GO:0006631 (P) fatty acid metabolic process [Q91WL5 ];
GO:0009308 (P) cellular amine metabolic process [P00184 ];
GO:0005792 (C) microsome [Q9JMA7, Q64459, P11714, Q64429, O09158, Q64481, P15392, P56657, Q6XVG2, P24456, Q64458, P56593, Q91WL5, O54750, Q91X77, P56654, P56656, Q91W64, P24457, Q05421, Q64462, Q8CIM7, Q9D816, Q9DBX6, P00186, P12790, O55071, P20852, P56655, Q9CX98, Q64464, O54749, P00184, P12791 ];
GO:0009791 (P) post-embryonic development [P00186 ];
GO:0055114 (P) oxidation reduction [Q9JMA7, Q64459, P11714, Q64429, O09158, Q64481, P15392, P56657, Q6XVG2, P24456, Q64458, P56593, Q91WL5, O54750, Q91X77, P56654, P56656, Q91W64, P24457, Q05421, Q64462, Q8CIM7, Q9D816, Q9DBX6, P00186, P12790, P28649, O55071, P20852, P56655, Q9CX98, Q64464, O54749, P00184, P12791 ];
GO:0017144 (P) drug metabolic process [P00186 ];

Subcellular localization

Localization

cell membrane [P28649 ];

endoplasmic reticulum [Q9JMA7, Q64459, P11714, Q64429, O09158, Q64481, P15392, P56657, Q6XVG2, P24456, Q64458, P56593, Q91WL5, O54750, Q91X77, P56654, P56656, Q91W64, P24457, Q05421, Q64462, Q8CIM7, Q9D816, Q9DBX6, P00186, P12790, O55071, P20852, P56655, Q9CX98, Q64464, O54749, P00184, P12791 ];

microsome [Q9JMA7, Q64459, P11714, Q64429, O09158, Q64481, P15392, P56657, Q6XVG2, P24456, Q64458, P56593, Q91WL5, O54750, Q91X77, P56654, P56656, Q91W64, P24457, Q05421, Q64462, Q8CIM7, Q9D816, Q9DBX6, P00186, P12790, O55071, P20852, P56655, Q9CX98, Q64464, O54749, P00184, P12791 ];

membrane [Q9JMA7, Q64459, P11714, Q64429, O09158, Q64481, P15392, P56657, Q6XVG2, P24456, Q64458, P56593, Q91WL5, O54750, Q91X77, P56654, P56656, Q91W64, P24457, Q05421, Q64462, Q8CIM7, Q9D816, P00186, Q9DBX6, P12790, O55071, P20852, P56655, Q64464, O54749, P00184, P12791 ];

Links

SwissProt

O09158; O54749; O54750; O55071; P00184; P00186; P11714; P12790; P12791; P15392; P20852; P24456; P24457; P28649; P56593; P56654; P56655; P56656; P56657; Q05421; Q64429; Q64458; Q64459; Q64462; Q64464; Q64481; Q6XVG2; Q8CIM7; Q91W64; Q91WL5; Q91X77; Q9CX98; Q9D816; Q9DBX6; Q9JMA7

Entrez Gene

107141; 13075; 13076; 13077; 13078; 13085; 13086; 13087; 13088; 13089; 13090; 13094; 13095; 13096; 13097; 13098; 13099; 13101; 13105; 13106; 13107; 13109; 13110; 13112; 13113; 13114; 13120; 226105; 226143; 337924; 404195; 53973; 56388; 56448; 69888; 72082; 72303; 74134; 74519; 76279; 81906



  Copyright 2009, Center for Bioinformatics 
  Last Modified: 2009-03-24  
  Design by Zhao Min