Center for Bioinformatics
Oxidoreductases | Transferases | Hydrolases | Lyases | Isomerases | Ligases

Basic Information

Enzyme Number

2.7.1.68

Official Name

1-phosphatidylinositol-4-phosphate 5-kinase

Name from literature

phosphatidylinositol phosphate kinase

Pathway from literature

PA biosynthesis

Pathway from KEGG

Cellular Processes; Cell Motility; Regulation of actin cytoskeleton; map04810

Environmental Information Processing; Signal Transduction; Phosphatidylinositol signaling system; map04070

Carbohydrate Metabolism; Inositol phosphate metabolism; map00562

Organisms

Mouse (10090)

Genome localization

11 D|11 58.2 cM[108083 ], 3 F2.1[18720 ], 10 D3[117150 ], 19 C1[18719 ], 1 C2[18711 ], 2 A3[18718 ], 10 C1[18717 ],

Comments

This enzyme can also phosphorylate PtdIns3P in the 4-position, and PtdIns, PtdIns3P and PtdIns(3,4)P2 in the 5-position in vitro, but to a lesser extent. The last of these reactions occurs in vivo and is physiologically relevant. Three different isoforms are known.

Rate-limiting Description

"Direct measurements of the activities of PtdIns kinase and PtdIns-P kinase in freeze-thawed cells revealed that the activity of PtdIns kinase was rate-limiting for the synthesis of PtdIns-P2." (3027078)

Regulatory Information

Regulatory type

Detail

phosphorylation;

O70161

phosphorylation;

P70181

phosphorylation;

P70182

phosphorylation;

Q9Z1T6

phosphorylation;

O70161:from_uniprot:644_Phosphotyrosine; by CSK

phosphorylation;

Q9Z1T6:from_uniprot:1154_Phosphotyrosine

phosphorylation;

Q9Z1T6:from_uniprot:1771_Phosphotyrosine

phosphorylation;

Q9Z1T6:from_uniprot:307_Phosphoserine

phosphorylation;

Q9Z1T6:from_uniprot:318_Phosphoserine

phosphorylation;

Q9Z1T6:from_uniprot:329_Phosphoserine

phosphorylation;

Q9Z1T6:from_uniprot:46_Phosphotyrosine

Gene ontology

Gene ontology

GO:0008270 (F) zinc ion binding [Q9Z1T6 ];
GO:0007242 (P) intracellular signaling cascade [Q9Z1T6 ];
GO:0016020 (C) membrane [Q6U7H8, P70181 ];
GO:0044267 (P) cellular protein metabolic process [Q9Z1T6 ];
GO:0005829 (C) cytosol [Q9Z1T6 ];
GO:0005737 (C) cytoplasm [Q6U7H8 ];
GO:0016308 (F) 1-phosphatidylinositol-4-phosphate 5-kinase... [Q9Z1T6, Q6U7H8, P70182, P70181, O70161 ];
GO:0005794 (C) Golgi apparatus [P70182 ];
GO:0005515 (F) protein binding [Q9Z1T6, Q6U7H8, P70182, P70181 ];
GO:0042995 (C) cell projection [Q6U7H8 ];
GO:0012505 (C) endomembrane system [P70181, O70161 ];
GO:0030054 (C) cell junction [O70161 ];
GO:0005886 (C) plasma membrane [P70182 ];
GO:0005524 (F) ATP binding [Q9Z1T6, Q6U7H8 ];
GO:0007409 (P) axonogenesis [O70161 ];
GO:0030659 (C) cytoplasmic vesicle membrane [Q9Z1T6 ];
GO:0046488 (P) phosphatidylinositol metabolic process [Q9Z1T6, Q6U7H8, P70182, P70181, O70161 ];

Subcellular localization

Localization

vesicle [Q9Z1T6, Q6U7H8 ];

cell membrane [Q9Z1T6, O70161 ];

golgi apparatus [P70182 ];

membrane [Q6U7H8, P70182, P70181 ];

cytoplasm [Q9Z1T6, Q6U7H8 ];

Links

SwissProt

O70161; P70181; P70182; Q6U7H8; Q9Z1T6

Entrez Gene

108083; 117150; 18711; 18717; 18718; 18719; 18720



  Copyright 2009, Center for Bioinformatics 
  Last Modified: 2009-03-24  
  Design by Zhao Min