Center for Bioinformatics
Oxidoreductases | Transferases | Hydrolases | Lyases | Isomerases | Ligases

Basic Information

Enzyme Number

1.3.3.6

Official Name

acyl-CoA oxidase

Name from literature

acyl CoA oxidase

Pathway from literature

very-long-chain fatty acid peroxisomal oxidation

Pathway from KEGG

Lipid Metabolism; Fatty acid metabolism; map00071

Cellular Processes; Endocrine System; PPAR signaling pathway; map03320

Lipid Metabolism; Biosynthesis of unsaturated fatty acids; map01040

Lipid Metabolism; alpha-Linolenic acid metabolism; map00592

Organisms

Rat (10116)

Genome localization

14q21[83522 ], 10q32.3[50681 ],

Comments

A flavoprotein (FAD). Acts on CoA derivatives of fatty acids with chain lengths from 8 to 18.

Rate-limiting Description

"Formalin-fixed, paraffin embedded liver sections from rats exposed to a Peroxisome Proliferator Activated Receptor (PPAR) agonist were stained with antibodies against peroxisomal targeting signal-1 (PTS-1) (a highly conserved tripeptide contained within all peroxisomal enzymes), Acyl CoA oxidase (AOX) (the rate limiting enzyme of peroxisomal beta oxidation), and catalase (an inducible peroxisomal antioxidant enzyme) to evaluate peroxisomal beta oxidation, oxidative stress, and peroxisome proliferation." (15805059)

"In the present study, the cloning, expression and characterization of the rate-limiting enzyme of the peroxisomal beta-oxidation spiral, acyl CoA oxidase (AOX), from koala (Phascolarctos cinereus) liver is described." (12758125)

Regulatory Information

Upstream transcription factor

25747

Regulatory type

Detail

phosphorylation;

P07872

phosphorylation;

P07872:from_uniprot:26_Phosphoserine

phosphorylation;

P07872:from_uniprot:310_Phosphoserine

phosphorylation;

P07872:from_uniprot:649_Phosphoserine

transcriptional factor;PPARalpha(25747)

"Differential regulation of the cynomolgus, human, and rat acyl-CoA oxidase promoters by PPARalpha." (16828988)

Gene ontology

Gene ontology

GO:0050660 (F) FAD binding [P07872, Q63448 ];
GO:0006693 (P) prostaglandin metabolic process [P07872 ];
GO:0006635 (P) fatty acid beta-oxidation [P07872, Q63448 ];
GO:0003995 (F) acyl-CoA dehydrogenase activity [P07872, Q63448 ];
GO:0009055 (F) electron carrier activity [P07872, Q63448 ];
GO:0006091 (P) generation of precursor metabolites and energy [P07872 ];
GO:0005777 (C) peroxisome [Q63448 ];
GO:0055114 (P) oxidation reduction [P07872, Q63448 ];
GO:0003997 (F) acyl-CoA oxidase activity [P07872, Q63448 ];

Subcellular localization

Localization

peroxisome [P07872, Q63448 ];

Links

SwissProt

P07872; Q63448

Entrez Gene

50681; 83522



  Copyright 2009, Center for Bioinformatics 
  Last Modified: 2009-03-24  
  Design by Zhao Min