Center for Bioinformatics
Oxidoreductases | Transferases | Hydrolases | Lyases | Isomerases | Ligases

Basic Information

Enzyme Number

3.1.3.4

Official Name

phosphatidate phosphatase

Name from literature

phosphatidate phosphohydrolase

Pathway from literature

triacylglycerol(TG) synthesis/the de novo synthesis of lipids and cholesterol

Pathway from KEGG

Lipid Metabolism; Sphingolipid metabolism; map00600

Lipid Metabolism; Glycerolipid metabolism; map00561

Lipid Metabolism; Ether lipid metabolism; map00565

Lipid Metabolism; Glycerophospholipid metabolism; map00564

Organisms

Rat (10116)

Genome localization

5q34[192270 ], 2q14[64369 ], 7q11[246115 ],

Rate-limiting Description

"The OA-feeding significantly increased the activity of hepatic microsomal phosphatidate phosphohydrolase (PAP), which is the rate-limiting enzyme for TG synthesis." (11678440)

"In contrast, phosphatidate phosphohydrolase, the rate-limiting enzyme for TG synthesis, was found to be 20% lower in the livers of the CLA-fed rats." (12359092)

"The activity of hepatic microsomal phosphocholine cytidyltransferase (the rate-limiting enzyme in phosphatidylcholine synthesis) was reduced significantly by L-NNA." (15539300)

"Further, a significant increase in the activity of carnitine palmitoyl transferase, a rate-limiting enzyme of fatty acid beta-oxidation, was found in the PC+OA group." (15975496)

"These results were attributed to the significant increases in the activities of phosphatidate phosphohydrolase (PAP), a rate-limiting enzyme of TG synthesis, and glucose-6-phosphate dehydrogenase, a fatty acid synthesis-related enzyme." (15527069)

Regulatory Information

Regulatory type

Detail

phosphorylation;

O08564

phosphorylation;

P97544:from_uniprot:110_Phosphotyrosine

phosphorylation;

Q7TMB7:from_uniprot:218_Phosphoserine

phosphorylation;

Q7TMB7:from_uniprot:347_Phosphoserine

phosphorylation;

Q7TMB7:from_uniprot:417_Phosphothreonine

transcriptional level;TGFbeta

"Transforming growth factor beta increases the activity of phosphatidate phosphohydrolase-1 in rat hepatocytes." (9016785)

Gene ontology

Gene ontology

GO:0005624 (C) membrane fraction [O08564 ];
GO:0016021 (C) integral to membrane [Q7TMB7, Q6W5G4, Q8K593, P97544, O08564, Q7TMB0 ];
GO:0008195 (F) phosphatidate phosphatase activity [Q7TMB7, Q6W5G4, Q8K593, P97544, O08564, Q7TMB0 ];
GO:0005886 (C) plasma membrane [O08564 ];
GO:0005789 (C) endoplasmic reticulum membrane [P97544 ];

Subcellular localization

Localization

cell membrane [O08564 ];

endoplasmic reticulum [P97544 ];

membrane [Q7TMB7, Q6W5G4, Q8K593, Q7TMB0 ];

Links

SwissProt

O08564; P97544; Q6W5G4; Q7TMB0; Q7TMB7; Q8K593

Entrez Gene

192270; 246115; 64369



  Copyright 2009, Center for Bioinformatics 
  Last Modified: 2009-03-24  
  Design by Zhao Min