Center for Bioinformatics
Oxidoreductases | Transferases | Hydrolases | Lyases | Isomerases | Ligases

Basic Information

Enzyme Number

1.2.4.1

Official Name

pyruvate dehydrogenase (acetyl-transferring)

Name from literature

pyruvate dehydrogenase

Pathway from literature

acetyl coenzyme A synthesis/synthesis of acetylcholine

Pathway from KEGG

Amino Acid Metabolism; Valine, leucine and isoleucine biosynthesis; map00290

Carbohydrate Metabolism; Pyruvate metabolism; map00620

Carbohydrate Metabolism; Glycolysis / Gluconeogenesis; map00010

Amino Acid Metabolism; Alanine and aspartate metabolism; map00252

Carbohydrate Metabolism; Butanoate metabolism; map00650

Organisms

Rat (10116)

Genome localization

15p14[289950 ], 2q44[117098 ], Xq21[29554 ],

Comments

Contains thiamine diphosphate. It is a component (in multiple copies) of the multienzyme pyruvate dehydrogenase complex in which it is bound to a core of molecules of EC 2.3.1.12, dihydrolipoyllysine-residue acetyltransferase, which also binds multiple copies of EC 1.8.1.4, dihydrolipoyl dehydrogenase. It does not act on free lipoamide or lipoyllysine, but only on the lipoyllysine residue in EC 2.3.1.12.

Rate-limiting Description

"The effects of trimetazidine on glucose oxidation were accompanied by a 37% increase in the active form of pyruvate dehydrogenase, the rate-limiting enzyme for glucose oxidation." (10720420)

Regulatory Information

Regulatory type

Detail

phosphorylation;

P26284

phosphorylation;

P26284:from_uniprot:232_Phosphoserine

phosphorylation;

P26284:from_uniprot:289_Phosphotyrosine

phosphorylation;

P26284:from_uniprot:293_Phosphoserine

phosphorylation;

P26284:from_uniprot:295_Phosphoserine

phosphorylation;

P26284:from_uniprot:300_Phosphoserine

phosphorylation;

P26284:from_uniprot:301_Phosphotyrosine

phosphorylation;

P49432:from_uniprot:67_Phosphotyrosine

phosphorylation;

Q06437:from_uniprot:290_Phosphotyrosine

phosphorylation;

Q06437:from_uniprot:294_Phosphoserine

phosphorylation;

Q06437:from_uniprot:301_Phosphoserine

phosphorylation;

Q06437:from_uniprot:302_Phosphotyrosine

Gene ontology

Gene ontology

GO:0005759 (C) mitochondrial matrix [P49432, P26284 ];
GO:0005739 (C) mitochondrion [Q06437 ];
GO:0006096 (P) glycolysis [P49432, P26284, Q06437 ];
GO:0004739 (F) pyruvate dehydrogenase (acetyl-transferring... [P49432, P26284, Q06437 ];
GO:0055114 (P) oxidation reduction [P49432, P26284, Q06437 ];

Subcellular localization

Localization

mitochondrion [P49432, P26284, Q06437 ];

Links

SwissProt

P26284; P49432; Q06437

Entrez Gene

117098; 289950; 29554



  Copyright 2009, Center for Bioinformatics 
  Last Modified: 2009-03-24  
  Design by Zhao Min