Center for Bioinformatics
Oxidoreductases | Transferases | Hydrolases | Lyases | Isomerases | Ligases

Basic Information

Enzyme Number

2.6.1.5

Official Name

tyrosine transaminase

Name from literature

tyrosine aminotransferase

Pathway from literature

catabolic pathway of tyrosine

Pathway from KEGG

Amino Acid Metabolism; Phenylalanine, tyrosine and tryptophan biosynthesis; map00400

Amino Acid Metabolism; Phenylalanine metabolism; map00360

Biosynthesis of Secondary Metabolites; Alkaloid biosynthesis I; map00950

Amino Acid Metabolism; Methionine metabolism; map00271

Biosynthesis of Secondary Metabolites; Novobiocin biosynthesis; map00401

Amino Acid Metabolism; Tyrosine metabolism; map00350

Organisms

Rat (10116)

Genome localization

19q11-q12[24813 ],

Comments

A pyridoxal-phosphate protein. L-Phenylalanine can act instead of L-tyrosine. The mitochondrial enzyme may be identical with EC 2.6.1.1 (aspartate transaminase). The three isoenzymic forms are interconverted by EC 3.4.22.32 (stem bromelain) and EC 3.4.22.33 (fruit bromelain). The enzyme can also catalyse the final step in the methionine-salvage pathway of Klebsiella pneumoniae [8].

Rate-limiting Description

"The major differences between the flight group and the synchronous control were elevations in microsomal protein, liver glycogen content, tyrosine aminotransferase, and tryptophan oxygenase and reductions in sphingolipids and the rate-limiting enzyme of heme biosynthesis, delta-aminolevulinic acid synthase." (1526942)

Gene ontology

Gene ontology

GO:0030170 (F) pyridoxal phosphate binding [P04694 ];
GO:0004838 (F) tyrosine transaminase activity [P04694 ];
GO:0009058 (P) biosynthetic process [P04694 ];
GO:0016847 (F) 1-aminocyclopropane-1-carboxylate synthase ... [P04694 ];
GO:0006559 (P) L-phenylalanine catabolic process [P04694 ];
GO:0006572 (P) tyrosine catabolic process [P04694 ];

Links

SwissProt

P04694

Entrez Gene

24813



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  Last Modified: 2009-03-24  
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