Center for Bioinformatics
Oxidoreductases | Transferases | Hydrolases | Lyases | Isomerases | Ligases

Basic Information

Enzyme Number

3.1.1.7

Official Name

acetylcholinesterase

Name from literature

acetylcholinesterase

Pathway from literature

acylation with certain substrates precedes general acid-base catalysis

Pathway from KEGG

Lipid Metabolism; Glycerophospholipid metabolism; map00564

Organisms

Rat (10116)

Genome localization

-[83817 ],

Comments

Acts on a variety of acetic esters; also catalyses transacetylations.

Rate-limiting Description

"To better understand the mechanisms of their modulatory effects and also other effects on the cholinergic system in the brain, the activities of ACh hydrolyzing enzyme acetylcholinesterase (AChE), ACh synthesizing enzyme choline acetyltransferase (ChAT) and ACh synthesizing rate-limiting step, high-affinity choline uptake (HACU) were examined in the present study." (15936353)

Gene ontology

Gene ontology

GO:0042802 (F) identical protein binding [P37136 ];
GO:0042135 (P) neurotransmitter catabolic process [P37136 ];
GO:0005576 (C) extracellular region [P37136 ];
GO:0031225 (C) anchored to membrane [P37136 ];
GO:0030054 (C) cell junction [P37136 ];
GO:0004104 (F) cholinesterase activity [P37136 ];
GO:0003990 (F) acetylcholinesterase activity [P37136 ];
GO:0045202 (C) synapse [P37136 ];

Subcellular localization

Localization

extracellular [P37136 ];

cell membrane [P37136 ];

synapse [P37136 ];

Links

SwissProt

P37136

Entrez Gene

83817



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  Last Modified: 2009-03-24  
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