Center for Bioinformatics
Oxidoreductases | Transferases | Hydrolases | Lyases | Isomerases | Ligases

Basic Information

Enzyme Number

3.1.1.7

Official Name

acetylcholinesterase

Name from literature

acetylcholinesterase

Pathway from literature

acylation with certain substrates precedes general acid-base catalysis

Pathway from KEGG

Lipid Metabolism; Glycerophospholipid metabolism; map00564

Organisms

Mouse (10090)

Genome localization

5 G2|5 77.0 cM[11423 ],

Comments

Acts on a variety of acetic esters; also catalyses transacetylations.

Rate-limiting Description

"Measurements of the activities of acetylcholinesterase (AChE) and choline acetyltransferase (ChAT), enzymes that hydrolyze and synthesize acetylcholine (ACh) and high-affinity choline uptake (HACU), a rate-limiting step in the synthesis of ACh, were determined in the presence of various concentrations of sodium azide in vitro." (12415870)

Regulatory Information

Upstream transcription factor

13653;20683

Regulatory type

Detail

transcriptional level;

"expression of PRiMA, as well as PRiMA-associated G(4) AChE, in muscle is suppressed by muscle regulatory factors, muscular activity, and nerve-derived trophic factors" (17324938)

transcriptional factor;Sp1(20683),Egr1(13653)

"Sp1 and Egr-1 compete for binding to overlapping sites and an increase in Egr-1 decreases the expression of the Ache gene." (7829523)

Gene ontology

Gene ontology

GO:0051262 (P) protein tetramerization [P21836 ];
GO:0043236 (F) laminin binding [P21836 ];
GO:0001919 (P) regulation of receptor recycling [P21836 ];
GO:0031623 (P) receptor internalization [P21836 ];
GO:0006581 (P) acetylcholine catabolic process [P21836 ];
GO:0005615 (C) extracellular space [P21836 ];
GO:0031225 (C) anchored to membrane [P21836 ];
GO:0030054 (C) cell junction [P21836 ];
GO:0004104 (F) cholinesterase activity [P21836 ];
GO:0003990 (F) acetylcholinesterase activity [P21836 ];
GO:0045202 (C) synapse [P21836 ];
GO:0043621 (F) protein self-association [P21836 ];
GO:0009986 (C) cell surface [P21836 ];
GO:0060041 (P) retina development in camera-type eye [P21836 ];
GO:0045212 (P) neurotransmitter receptor biosynthetic process [P21836 ];

Subcellular localization

Localization

extracellular [P21836 ];

cell membrane [P21836 ];

synapse [P21836 ];

Links

SwissProt

P21836

Entrez Gene

11423



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  Last Modified: 2009-03-24  
  Design by Zhao Min