Center for Bioinformatics
Oxidoreductases | Transferases | Hydrolases | Lyases | Isomerases | Ligases

Basic Information

Enzyme Number

1.3.99.5

Official Name

3-oxo-5alpha-steroid 4-dehydrogenase

Name from literature

steroid alpha reductase

Pathway from literature

the production of 5 alpha-reduced steroids

Pathway from KEGG

Lipid Metabolism; Androgen and estrogen metabolism; map00150

Lipid Metabolism; Bile acid biosynthesis; map00120

Human Diseases; Cancers; Prostate cancer; map05215

Organisms

Rat (10116)

Genome localization

6q13[64677 ], 17p14[24950 ],

Rate-limiting Description

"Steroid 5 alpha-reductase is the rate-limiting enzyme in the production of 5 alpha-reduced steroids in many tissues." (7588289)

"These findings confirm the role of 5alpha-reductase as a rate-limiting step in the metabolism of norethisterone derivatives and show important inhibitory effects of substituents at the 7alpha- and 11-position of the steroid skeleton on 5alpha-reduction." (11408363)

Gene ontology

Gene ontology

GO:0030154 (P) cell differentiation [P24008, P31214 ];
GO:0008202 (P) steroid metabolic process [P24008 ];
GO:0016021 (C) integral to membrane [P24008, P31214 ];
GO:0007530 (P) sex determination [P24008, P31214 ];
GO:0005792 (C) microsome [P24008, P31214 ];
GO:0003865 (F) 3-oxo-5-alpha-steroid 4-dehydrogenase activity [Q71VC1, P24008, P31214 ];
GO:0055114 (P) oxidation reduction [Q71VC1, P24008, P31214 ];
GO:0005789 (C) endoplasmic reticulum membrane [P24008, P31214 ];

Subcellular localization

Localization

endoplasmic reticulum [P24008, P31214 ];

microsome [P24008, P31214 ];

Links

SwissProt

P24008; P31214; Q71VC1

Entrez Gene

24950; 64677



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  Last Modified: 2009-03-24  
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