Center for Bioinformatics
Oxidoreductases | Transferases | Hydrolases | Lyases | Isomerases | Ligases

Basic Information

Enzyme Number

1.1.1.37

Official Name

malate dehydrogenase

Name from literature

malate dehydrogenase

Pathway from literature

the NADH shuttle that produces ATP in glucose metabolism

Pathway from KEGG

Carbohydrate Metabolism; Pyruvate metabolism; map00620

Energy Metabolism; Reductive carboxylate cycle (CO2 fixation); map00720

Carbohydrate Metabolism; Glyoxylate and dicarboxylate metabolism; map00630

Carbohydrate Metabolism; Citrate cycle (TCA cycle); map00020

Energy Metabolism; Carbon fixation; map00710

Organisms

Mouse (10090)

Genome localization

5 G2|5 78.0 cM[17448 ], 11 A3.1|11 12.0 cM[17449 ],

Comments

Also oxidizes some other 2-hydroxydicarboxylic acids.

Rate-limiting Description

"The activity of triokinase also increased on the sucrose diet in the 3 rodent species, suggesting a coordinative substrate effect on the induction of these two rate-limiting fructolysis enzymes.(ABSTRACT TRUNCATED AT 250 WORDS)FAU - Shafrir, E." (6088170)

Regulatory Information

Upstream transcription factor

20683

Regulatory type

Detail

phosphorylation;

P08249

phosphorylation;

P14152

phosphorylation;

P08249:from_uniprot:56_Phosphotyrosine

phosphorylation;

P14152:from_uniprot:210_Phosphotyrosine

transcriptional factor;Sp1(20683)

"The 5' end of the gene lacks the TATA and CAAT boxes characteristic of eukaryotic promoters, but contains G + C-rich sequences, one putative binding site for a cellular transcription factor, Sp1, and at least two major transcription-initiation sites." (3172222#3379635)

Gene ontology

Gene ontology

GO:0006096 (P) glycolysis [P14152, P08249 ];
GO:0006108 (P) malate metabolic process [P14152, P08249 ];
GO:0005737 (C) cytoplasm [P14152 ];
GO:0006099 (P) tricarboxylic acid cycle [P14152, P08249 ];
GO:0005759 (C) mitochondrial matrix [P08249 ];
GO:0005488 (F) binding [P08249 ];
GO:0005743 (C) mitochondrial inner membrane [P08249 ];
GO:0030060 (F) L-malate dehydrogenase activity [P14152, P08249 ];
GO:0055114 (P) oxidation reduction [P14152, P08249 ];

Subcellular localization

Localization

mitochondrion [P08249 ];

cytoplasm [P14152 ];

Links

SwissProt

P08249; P14152

Entrez Gene

17448; 17449



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  Last Modified: 2009-03-24  
  Design by Zhao Min