Center for Bioinformatics
Oxidoreductases | Transferases | Hydrolases | Lyases | Isomerases | Ligases

Basic Information

Enzyme Number

2.5.1.10

Official Name

geranyltranstransferase

Name from literature

farnesyl diphosphate synthetase

Pathway from literature

ergosterol biosynthesis in yeast

Pathway from KEGG

Biosynthesis of Secondary Metabolites; Terpenoid biosynthesis; map00900

Lipid Metabolism; Biosynthesis of steroids; map00100

Organisms

Yeast (4932)

Genome localization

-[856036 ], -[853272 ],

Comments

Some forms of this enzyme will also use dimethylallyl diphosphate as a substrate. The enzyme will not accept larger prenyl diphosphates as efficient donors.

Rate-limiting Description

"The isolation of the functional ERG20 gene allowed us to show that farnesyl diphosphate synthetase could be a rate limiting enzyme in ergosterol biosynthesis in yeast." (1779710)

Regulatory Information

Upstream transcription factor

851136

Regulatory type

Detail

transcriptional factor;CDC73(851136)

"A Snf2 family ATPase complex required for recruitment of the histone H2A variant Htz1." (14690608#14764870)

Gene ontology

Gene ontology

GO:0004337 (F) geranyltranstransferase activity [P08524, Q12051 ];
GO:0016117 (P) carotenoid biosynthetic process [Q12051 ];
GO:0015031 (P) protein transport [Q12051 ];
GO:0005739 (C) mitochondrion [Q12051 ];
GO:0005737 (C) cytoplasm [P08524 ];
GO:0006695 (P) cholesterol biosynthetic process [P08524 ];
GO:0004311 (F) farnesyltranstransferase activity [Q12051 ];
GO:0045337 (P) farnesyl diphosphate biosynthetic process [P08524 ];
GO:0004161 (F) dimethylallyltranstransferase activity [P08524, Q12051 ];
GO:0005515 (F) protein binding [P08524 ];

Subcellular localization

Localization

cytoplasm [P08524, Q12051 ];

Links

SwissProt

P08524; Q12051

Entrez Gene

853272; 856036



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  Last Modified: 2009-03-24  
  Design by Zhao Min