Center for Bioinformatics
Oxidoreductases | Transferases | Hydrolases | Lyases | Isomerases | Ligases

Basic Information

Enzyme Number

2.4.1.45

Official Name

2-hydroxyacylsphingosine 1-beta-galactosyltransferase

Name from literature

ceramide galactosyltransferase

Pathway from literature

cerebroside synthesis

Organisms

Rat (10116)

Comments

Highly specific.

Rate-limiting Description

"With increasing dose and increasing exposure times, there was an increasing degree of demyelination and increasing down-regulation of mRNA levels for myelin P0 protein, ceramide galactosyltransferase (rate-limiting enzyme in cerebroside synthesis), and HMG-CoA reductase (rate-limiting enzyme in cholesterol synthesis)." (9387870)

"We found that, during development of the rat sciatic nerve, expression of mRNA for hydroxymethylglutaryl-coenzyme A (HMG-CoA) reductase, the rate-limiting enzyme in cholesterol biosynthesis, was up-regulated in parallel with mRNA for P0, the major structural protein of PNS myelin, and with ceramide galactosyltransferase (CGT), the rate-limiting enzyme in cerebroside biosynthesis." (9681444)

Gene ontology

Gene ontology

GO:0016021 (C) integral to membrane [Q09426 ];
GO:0003851 (F) 2-hydroxyacylsphingosine 1-beta-galactosylt... [Q09426 ];
GO:0008152 (P) metabolic process [Q09426 ];

Subcellular localization

Localization

membrane [Q09426 ];

Links

SwissProt

Q09426



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  Last Modified: 2009-03-24  
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