Center for Bioinformatics
Oxidoreductases | Transferases | Hydrolases | Lyases | Isomerases | Ligases

Basic Information

Enzyme Number

4.2.1.1

Official Name

carbonate dehydratase

Name from literature

carbonic anhydrase

Pathway from literature

CO2 hydration

Pathway from KEGG

Energy Metabolism; Nitrogen metabolism; map00910

Organisms

Mouse (10090)

Genome localization

8 D1[12354 ], 8 E1|8 67.0 cM[12352 ], 9 C[76459 ], 11 C[12351 ], 3 A1|3 10.5 cM[12349 ], 3 A1|3 10.5 cM[12346 ], 3 F2.1[23831 ], 4 B1[230099 ], X F5[56078 ], 3 A2|3 11.7 cM[12350 ], 4 E2[12353 ],

Comments

A zinc protein.

Rate-limiting Description

"The rate-limiting step in the catalysis of the hydration of CO2 by carbonic anhydrase involves transfer of protons between zinc-bound water and solution." (9882455)

Regulatory Information

Upstream transcription factor

13198;21833

Regulatory type

Detail

phosphorylation;

P00920

phosphorylation;

Q8CI85

phosphorylation;

Q8VHB5

phosphorylation;

Q9WVT6

phosphorylation;

P00920:from_uniprot:87_Phosphoserine

transcriptional level;"Estrogen receptor ,"

"Estrogen receptor regulation of carbonic anhydrase XII through a distal enhancer in breast cancer." (18451179)

transcriptional factor;GADD153(13198)

"CHOP-Dependent stress-inducible expression of a novel form of carbonic anhydrase VI." (9858573)

transcriptional factor;ErbA(21833)

"ErbA is unable to bind ligand, and hence is thought to contribute to leukemogenesis by actively repressing erythroid-specific genes such as the carbonic anhydrase II gene (CA II). " (11314012)

Gene ontology

Gene ontology

GO:0042995 (C) cell projection [Q8VHB5 ];
GO:0008270 (F) zinc ion binding [Q8CI85, Q64444, P13634, Q99N23, P18761, Q9D6N1, P16015, Q9QZA0, Q9WVT6, P00920, Q8VHB5, Q9ERQ8, P23589 ];
GO:0004089 (F) carbonate dehydratase activity [Q8CI85, Q64444, P13634, Q99N23, P18761, Q9D6N1, P16015, Q9QZA0, Q9WVT6, P00920, Q8VHB5, Q9ERQ8, P23589 ];
GO:0006094 (P) gluconeogenesis [P23589 ];
GO:0031225 (C) anchored to membrane [Q64444 ];
GO:0005739 (C) mitochondrion [Q9QZA0, P23589 ];
GO:0005886 (C) plasma membrane [Q64444, Q8VHB5 ];
GO:0005737 (C) cytoplasm [P13634, P00920, Q9ERQ8, P16015 ];
GO:0046903 (P) secretion [Q8VHB5, P00920 ];
GO:0002009 (P) morphogenesis of an epithelium [Q8VHB5, P00920 ];
GO:0016021 (C) integral to membrane [Q8CI85, Q9WVT6, Q8VHB5 ];
GO:0015670 (P) carbon dioxide transport [P00920 ];
GO:0005576 (C) extracellular region [Q99N23, P18761 ];
GO:0016151 (F) nickel ion binding [P16015 ];
GO:0006730 (P) one-carbon compound metabolic process [Q8CI85, Q64444, P13634, Q99N23, P18761, Q9D6N1, P16015, Q9QZA0, Q9WVT6, P00920, Q8VHB5, Q9ERQ8, P23589 ];

Subcellular localization

Localization

cell membrane [Q8CI85, Q9WVT6, Q64444, Q8VHB5 ];

mitochondrion [Q9QZA0, P23589 ];

extracellular [Q99N23, P18761 ];

cytoplasm [P13634, P00920, Q9ERQ8, P16015 ];

Links

SwissProt

P00920; P13634; P16015; P18761; P23589; Q64444; Q8CI85; Q8VHB5; Q99N23; Q9D6N1; Q9ERQ8; Q9QZA0; Q9WVT6

Entrez Gene

12346; 12349; 12350; 12351; 12352; 12353; 12354; 230099; 23831; 56078; 76459



  Copyright 2009, Center for Bioinformatics 
  Last Modified: 2009-03-24  
  Design by Zhao Min