Center for Bioinformatics
Oxidoreductases | Transferases | Hydrolases | Lyases | Isomerases | Ligases

Basic Information

Enzyme Number

2.4.1.11

Official Name

glycogen(starch) synthase

Name from literature

glycogen synthase

Pathway from literature

nonoxidative pathway/glycogen synthesis of skeletal muscle

Pathway from KEGG

Cellular Processes; Endocrine System; Insulin signaling pathway; map04910

Carbohydrate Metabolism; Starch and sucrose metabolism; map00500

Organisms

Rat (10116)

Genome localization

4q44[25623 ],

Comments

The accepted name varies according to the source of the enzyme and the nature of its synthetic product (cf. EC 2.4.1.1, phosphorylase). Glycogen synthase from animal tissues is a complex of a catalytic subunit and the protein glycogenin. The enzyme requires glucosylated glycogenin as a primer; this is the reaction product of EC 2.4.1.186 (glycogenin glucosyltransferase). A similar enzyme utilizes ADP-glucose (EC 2.4.1.21, starch synthase).

Rate-limiting Description

"As the GPI-PLC reaction is rate limiting, the efficiency of the two-step anchor cleavage was significantly increased when insulin was present together with glucose as compared to glucose alone." (10684630)

Regulatory Information

Regulatory type

Detail

phosphorylation;

P17625

phosphorylation;

P17625:from_uniprot:11_Phosphoserine

phosphorylation;

P17625:from_uniprot:6_Phosphoserine

phosphorylation;

P17625:from_uniprot:625_Phosphothreonine

phosphorylation;

P17625:from_uniprot:640_Phosphoserine

phosphorylation;

P17625:from_uniprot:644_Phosphoserine

phosphorylation;

P17625:from_uniprot:648_Phosphoserine

phosphorylation;

P17625:from_uniprot:652_Phosphoserine

phosphorylation;

P17625:from_uniprot:656_Phosphoserine

phosphorylation;

P17625:from_uniprot:8_Phosphoserine; by PKA

transcriptional level;TNF alpha

"TNF-alpha also blocked insulin activation of glycogen synthase (GS) and inhibited glycogen synthesis." (8641197)

Gene ontology

Gene ontology

GO:0030864 (C) cortical actin cytoskeleton [P17625 ];
GO:0005978 (P) glycogen biosynthetic process [Q99MF8, P17625 ];
GO:0009749 (P) response to glucose stimulus [P17625 ];
GO:0004373 (F) glycogen (starch) synthase activity [Q7M072, Q99MF8, P17625 ];
GO:0005625 (C) soluble fraction [P17625 ];
GO:0005626 (C) insoluble fraction [P17625 ];
GO:0005829 (C) cytosol [P17625 ];
GO:0043265 (C) ectoplasm [P17625 ];

Links

SwissProt

P17625; Q7M072; Q99MF8

Entrez Gene

25623



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  Last Modified: 2009-03-24  
  Design by Zhao Min