Center for Bioinformatics
Oxidoreductases | Transferases | Hydrolases | Lyases | Isomerases | Ligases

Basic Information

Enzyme Number

2.4.1.11

Official Name

glycogen(starch) synthase

Name from literature

glycogen synthase

Pathway from literature

nonoxidative pathway/glycogen synthesis of skeletal muscle

Pathway from KEGG

Cellular Processes; Endocrine System; Insulin signaling pathway; map04910

Carbohydrate Metabolism; Starch and sucrose metabolism; map00500

Organisms

Yeast (4932)

Genome localization

-[850569 ], -[850962 ],

Comments

The accepted name varies according to the source of the enzyme and the nature of its synthetic product (cf. EC 2.4.1.1, phosphorylase). Glycogen synthase from animal tissues is a complex of a catalytic subunit and the protein glycogenin. The enzyme requires glucosylated glycogenin as a primer; this is the reaction product of EC 2.4.1.186 (glycogenin glucosyltransferase). A similar enzyme utilizes ADP-glucose (EC 2.4.1.21, starch synthase).

Rate-limiting Description

"As the GPI-PLC reaction is rate limiting, the efficiency of the two-step anchor cleavage was significantly increased when insulin was present together with glucose as compared to glucose alone." (10684630)

Regulatory Information

Upstream transcription factor

856076

Regulatory type

Detail

phosphorylation;

P23337:from_uniprot:159_Phosphoserine

phosphorylation;

P23337:from_uniprot:363_Phosphoserine

phosphorylation;

P23337:from_uniprot:560_Phosphoserine

phosphorylation;

P23337:from_uniprot:651_Phosphoserine

phosphorylation;

P23337:from_uniprot:655_Phosphoserine

phosphorylation;

P23337:from_uniprot:660_Phosphoserine; by PKA

phosphorylation;

P23337:from_uniprot:662_Phosphoserine; by PKA

phosphorylation;

P27472:from_uniprot:159_Phosphoserine

phosphorylation;

P27472:from_uniprot:363_Phosphoserine

phosphorylation;

P27472:from_uniprot:467_Phosphoserine

phosphorylation;

P27472:from_uniprot:651_Phosphoserine

phosphorylation;

P27472:from_uniprot:655_Phosphoserine; by PHO85

phosphorylation;

P27472:from_uniprot:661_Phosphoserine; by PKA

phosphorylation;

P27472:from_uniprot:663_Phosphoserine; by PKA

phosphorylation;

P27472:from_uniprot:668_Phosphothreonine; by PHO85

transcriptional factor;PHO85(856076)

"Cyclin partners determine Pho85 protein kinase substrate specificity in vitro and in vivo: control of glycogen biosynthesis by Pcl8 and Pcl10." (9584169#10490639)

Gene ontology

Gene ontology

GO:0005978 (P) glycogen biosynthetic process [P27472, P23337 ];
GO:0042802 (F) identical protein binding [P27472, P23337 ];
GO:0004373 (F) glycogen (starch) synthase activity [P27472, P23337 ];
GO:0005739 (C) mitochondrion [P23337 ];
GO:0005737 (C) cytoplasm [P27472 ];

Links

SwissProt

P23337; P27472

Entrez Gene

850569; 850962



  Copyright 2009, Center for Bioinformatics 
  Last Modified: 2009-03-24  
  Design by Zhao Min