Center for Bioinformatics
Oxidoreductases | Transferases | Hydrolases | Lyases | Isomerases | Ligases

Basic Information

Enzyme Number

1.13.11.11

Official Name

tryptophan 2,3-dioxygenase

Name from literature

tryptophan 2,3-dioxygenase

Pathway from literature

kynurenine pathway/tryptophan catabolism

Pathway from KEGG

Amino Acid Metabolism; Tryptophan metabolism; map00380

Organisms

Rat (10116)

Genome localization

2q33[64206 ],

Comments

A protohemoprotein. In mammals, the enzyme appears to be located only in the liver. This enzyme, together with EC 1.13.11.52, indoleamine 2,3-dioxygenase, catalyses the first and rate-limiting step in the kynurenine pathway, the major pathway of tryptophan metabolism [5]. The enzyme is specific for tryptophan as substrate, but is far more active with L-tryptophan than with D-tryptophan [2].

Rate-limiting Description

"Liver L-tryptophan 2,3-dioxygenase activity (TDO), a rate-limiting enzyme of the kynurenine pathway, was increased in proportion to blood urea nitrogen and creatinine levels." (10966936)

Regulatory Information

Upstream transcription factor

24413

Regulatory type

Detail

phosphorylation;

P21643:from_uniprot:155_Phosphoserine

phosphorylation;

P21643:from_uniprot:19_Phosphoserine

transcriptional factor;glucocorticoid receptor(24413)

"Glucocorticoid induction of the rat tryptophan oxygenase gene is mediated by two widely separated glucocorticoid-responsive elements.#Nucleotide sequence of a fragment of the rat tryptophan oxygenase gene showing high affinity to glucocorticoid receptor in vitro." (1511007#3582368)

Gene ontology

Gene ontology

GO:0019441 (P) tryptophan catabolic process to kynurenine [P21643 ];
GO:0055114 (P) oxidation reduction [P21643 ];
GO:0005506 (F) iron ion binding [P21643 ];
GO:0004833 (F) tryptophan 2, 3-dioxygenase activity [P21643 ];

Links

SwissProt

P21643

Entrez Gene

64206



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  Last Modified: 2009-03-24  
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