Center for Bioinformatics
Oxidoreductases | Transferases | Hydrolases | Lyases | Isomerases | Ligases

Basic Information

Enzyme Number

6.2.1.5

Official Name

succinate---CoA ligase (ADP-forming)

Name from literature

ATP-dependent citrate lyase

Pathway from literature

the de novo synthesis of lipids and cholesterol

Pathway from KEGG

Carbohydrate Metabolism; C5-Branched dibasic acid metabolism; map00660

Carbohydrate Metabolism; Propanoate metabolism; map00640

Energy Metabolism; Reductive carboxylate cycle (CO2 fixation); map00720

Carbohydrate Metabolism; Citrate cycle (TCA cycle); map00020

Organisms

Mouse (10090)

Genome localization

14 D3[20916 ],

Rate-limiting Description

"The mode of action of these compounds in the 50-100 microM concentration range appeared to be by increasing lipid excretion from the body and by inhibiting rate-limiting enzyme activities for the de novo synthesis of lipids and cholesterol (e.g., phosphatidylate phosphohydrolase, ATP-dependent citrate lyase, cytoplasmic acetyl coenzyme A ." (CoA synthetase, HMG CoA reductase, and acetyl CoA carboxylase))

"These data indicate preferential localization of ATP-citrate lyase in cholinergic nerve endings, and indicate that this enzyme is not a rate limiting step in the synthesis of the acetyl moiety of ACh in brain.." (6109001)

Regulatory Information

Regulatory type

Detail

phosphorylation;

Q9Z2I9

phosphorylation;

Q9Z2I9:from_uniprot:279_Phosphoserine

phosphorylation;

Q9Z2I9:from_uniprot:84_Phosphotyrosine

Gene ontology

Gene ontology

GO:0006099 (P) tricarboxylic acid cycle [Q9Z2I9 ];
GO:0005739 (C) mitochondrion [Q9Z2I9 ];
GO:0004775 (F) succinate-CoA ligase (ADP-forming) activity [Q9Z2I9 ];
GO:0005524 (F) ATP binding [Q9Z2I9 ];

Subcellular localization

Localization

mitochondrion [Q9Z2I9 ];

Links

SwissProt

Q9Z2I9

Entrez Gene

20916



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  Last Modified: 2009-03-24  
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