Center for Bioinformatics
Oxidoreductases | Transferases | Hydrolases | Lyases | Isomerases | Ligases

Basic Information

Enzyme Number

2.7.1.91

Official Name

sphinganine kinase

Name from literature

sphingosine kinase

Pathway from literature

synthesis of sphingosine 1-phosphate

Pathway from KEGG

Lipid Metabolism; Sphingolipid metabolism; map00600

Environmental Information Processing; Signal Transduction; Calcium signaling pathway; map04020

Environmental Information Processing; Signal Transduction; VEGF signaling pathway; map04370

Organisms

Rat (10116)

Genome localization

10q32.3[170897 ], 1q22[308589 ],

Rate-limiting Description

"These signalling events downstream of lpR activation were inhibited to varying degrees by pertussis toxin (PTX) pretreatment or by the inhibition of sphingosine kinase (SK), a rate-limiting enzyme in the biosynthesis of S1P from sphingosine." (14568343)

Regulatory Information

Regulatory type

Detail

phosphorylation;

Q91V26:from_uniprot:193_Phosphothreonine

Gene ontology

Gene ontology

GO:0000287 (F) magnesium ion binding [Q91V26 ];
GO:0005516 (F) calmodulin binding [Q91V26 ];
GO:0004143 (F) diacylglycerol kinase activity [Q91V26 ];
GO:0007205 (P) activation of protein kinase C activity [Q91V26 ];
GO:0017050 (F) D-erythro-sphingosine kinase activity [Q91V26 ];
GO:0008481 (F) sphinganine kinase activity [Q91V26 ];
GO:0005524 (F) ATP binding [Q91V26 ];

Links

SwissProt

Q91V26

Entrez Gene

170897; 308589



  Copyright 2009, Center for Bioinformatics 
  Last Modified: 2009-03-24  
  Design by Zhao Min