Center for Bioinformatics
Oxidoreductases | Transferases | Hydrolases | Lyases | Isomerases | Ligases

Basic Information

Enzyme Number

2.7.1.91

Official Name

sphinganine kinase

Name from literature

sphingosine kinase

Pathway from literature

synthesis of sphingosine 1-phosphate

Pathway from KEGG

Lipid Metabolism; Sphingolipid metabolism; map00600

Environmental Information Processing; Signal Transduction; Calcium signaling pathway; map04020

Environmental Information Processing; Signal Transduction; VEGF signaling pathway; map04370

Organisms

Mouse (10090)

Genome localization

11 E2[20698 ], 7 B4[56632 ],

Rate-limiting Description

"BACKGROUND: Phosphorylation of sphingosine by sphingosine kinase (SK) is the rate-limiting step in the cellular synthesis of sphingosine 1-phosphate (S1P)." (15451787)

Regulatory Information

Regulatory type

Detail

phosphorylation;

Q8CI15:from_uniprot:193_Phosphothreonine

phosphorylation;

Q9JIA7:from_uniprot:364_Phosphoserine

Gene ontology

Gene ontology

GO:0005624 (C) membrane fraction [Q9JIA7 ];
GO:0000287 (F) magnesium ion binding [Q8CI15 ];
GO:0006954 (P) inflammatory response [Q8CI15 ];
GO:0006669 (P) sphinganine-1-phosphate biosynthetic process [Q9JIA7 ];
GO:0005829 (C) cytosol [Q9JIA7 ];
GO:0008284 (P) positive regulation of cell proliferation [Q9JIA7, Q8CI15 ];
GO:0006670 (P) sphingosine metabolic process [Q9JIA7 ];
GO:0007205 (P) activation of protein kinase C activity [Q9JIA7, Q8CI15 ];
GO:0005515 (F) protein binding [Q9JIA7 ];
GO:0004143 (F) diacylglycerol kinase activity [Q9JIA7, Q8CI15 ];
GO:0008481 (F) sphinganine kinase activity [Q9JIA7, Q8CI15 ];
GO:0005524 (F) ATP binding [Q9JIA7, Q8CI15 ];
GO:0001568 (P) blood vessel development [Q9JIA7, Q8CI15 ];
GO:0006916 (P) anti-apoptosis [Q9JIA7 ];
GO:0005516 (F) calmodulin binding [Q8CI15 ];
GO:0017050 (F) D-erythro-sphingosine kinase activity [Q9JIA7, Q8CI15 ];
GO:0032651 (P) regulation of interleukin-1 beta production [Q8CI15 ];
GO:0007420 (P) brain development [Q9JIA7, Q8CI15 ];

Links

SwissProt

Q8CI15; Q9JIA7

Entrez Gene

20698; 56632



  Copyright 2009, Center for Bioinformatics 
  Last Modified: 2009-03-24  
  Design by Zhao Min