2.7.1.91

sphinganine kinase

sphingosine kinase

synthesis of sphingosine 1-phosphate

Mouse (10090)

11 E2[20698 ], 7 B4[56632 ],

"BACKGROUND: Phosphorylation of sphingosine by sphingosine kinase (SK) is the rate-limiting step in the cellular synthesis of sphingosine 1-phosphate (S1P)." (15451787)

phosphorylation;

phosphorylation;

GO:0005624 (C) membrane fraction [Q9JIA7 ];
GO:0000287 (F) magnesium ion binding [Q8CI15 ];
GO:0006954 (P) inflammatory response [Q8CI15 ];
GO:0006669 (P) sphinganine-1-phosphate biosynthetic process [Q9JIA7 ];
GO:0005829 (C) cytosol [Q9JIA7 ];
GO:0008284 (P) positive regulation of cell proliferation [Q9JIA7, Q8CI15 ];
GO:0006670 (P) sphingosine metabolic process [Q9JIA7 ];
GO:0007205 (P) activation of protein kinase C activity [Q9JIA7, Q8CI15 ];
GO:0005515 (F) protein binding [Q9JIA7 ];
GO:0004143 (F) diacylglycerol kinase activity [Q9JIA7, Q8CI15 ];
GO:0008481 (F) sphinganine kinase activity [Q9JIA7, Q8CI15 ];
GO:0005524 (F) ATP binding [Q9JIA7, Q8CI15 ];
GO:0001568 (P) blood vessel development [Q9JIA7, Q8CI15 ];
GO:0006916 (P) anti-apoptosis [Q9JIA7 ];
GO:0005516 (F) calmodulin binding [Q8CI15 ];
GO:0017050 (F) D-erythro-sphingosine kinase activity [Q9JIA7, Q8CI15 ];
GO:0032651 (P) regulation of interleukin-1 beta production [Q8CI15 ];
GO:0007420 (P) brain development [Q9JIA7, Q8CI15 ];

Q8CI15; Q9JIA7

20698; 56632