Center for Bioinformatics
Oxidoreductases | Transferases | Hydrolases | Lyases | Isomerases | Ligases

Basic Information

Enzyme Number

1.1.1.205

Official Name

IMP dehydrogenase

Name from literature

Inosine monophosphate dehydrogenase

Pathway from literature

the de novo synthesis of guanine nucleotides from IMP

Pathway from KEGG

Nucleotide Metabolism; Purine metabolism; map00230

Xenobiotics Biodegradation and Metabolism; Drug metabolism - other enzymes; map00983

Organisms

Rat (10116)

Genome localization

8q32[301005 ], 4q22[362329 ],

Comments

The enzyme acts on the hydroxy group of the hydrated derivative of the substrate.

Rate-limiting Description

"Mycophenolic acid (MPA) is a highly selective, non-competitive and reversible inhibitor of the inosine monophosphate dehydrogenase (IMPDH), the rate-limiting enzyme in the de novo biosynthesis of guanosine nucleotides." (17100698)

Links

Entrez Gene

301005; 362329



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  Last Modified: 2009-03-24  
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