Center for Bioinformatics
Oxidoreductases | Transferases | Hydrolases | Lyases | Isomerases | Ligases

Basic Information

Enzyme Number

1.1.1.205

Official Name

IMP dehydrogenase

Name from literature

Inosine monophosphate dehydrogenase

Pathway from literature

the de novo synthesis of guanine nucleotides from IMP

Pathway from KEGG

Nucleotide Metabolism; Purine metabolism; map00230

Xenobiotics Biodegradation and Metabolism; Drug metabolism - other enzymes; map00983

Organisms

Yeast (4932)

Genome localization

-[856626 ], -[854948 ], -[851152 ],

Comments

The enzyme acts on the hydroxy group of the hydrated derivative of the substrate.

Rate-limiting Description

"IMP dehydrogenase (IMPDH) is the rate-limiting enzyme in the de novo synthesis of guanine nucleotides." (11003640)

"IMP dehydrogenase (IMPDH) catalyzes the rate-limiting step in the de novo synthesis of GTP." (12746440)

"IMP dehydrogenase is a rate-limiting enzyme involved in the synthesis of GTP." (11441018)

"IMP dehydrogenase (IMPDH) is the rate-limiting enzyme for de novo GMP synthesis." (15292516)

Regulatory Information

Upstream transcription factor

854999;850594;851415;852931;851745;855491;855708;850691;851906

Regulatory type

Detail

phosphorylation;

P39567:from_uniprot:129_Phosphoserine

phosphorylation;

P50094:from_uniprot:125_Phosphoserine

phosphorylation;

P50094:from_uniprot:168_Phosphoserine

transcriptional factor;SPT5(854999)

"Dual roles for Spt5 in pre-mRNA processing and transcription elongation revealed by identification of Spt5-associated proteins." (12556496)

transcriptional factor;PHO4(850594)

"Applicability of tandem affinity purification MudPIT to pathway proteomics in yeast." (14660704)

transcriptional factor;RPO21(851415)

"Regulation of an IMP dehydrogenase gene and its overexpression in drug-sensitive transcription elongation mutants of yeast." (11441018)

transcriptional factor;KSS1(852931)

"Global analysis of protein phosphorylation in yeast." (16319894)

interact with TF;TAF10(851745)

"A comprehensive analysis of protein-protein interactions in Saccharomyces cerevisiae." (10688190)

interact with TF;ELA1(855491)

"Systematic identification of protein complexes in Saccharomyces cerevisiae by mass spectrometry." (11805837)

interact with TF;FAP1(855708)

"Proteome survey reveals modularity of the yeast cell machinery." (16429126)

interact with TF;SSL1(850691)

"Proteome survey reveals modularity of the yeast cell machinery." (16429126)

interact with TF;TFB1(851906)

"Proteome survey reveals modularity of the yeast cell machinery." (16429126)

interact with TF;ELA1(855491)

"Systematic identification of protein complexes in Saccharomyces cerevisiae by mass spectrometry." (11805837)

Gene ontology

Gene ontology

GO:0006177 (P) GMP biosynthetic process [P50095, P50094, P39567, P38697 ];
GO:0006183 (P) GTP biosynthetic process [P50095, P38697 ];
GO:0030955 (F) potassium ion binding [P50095, P50094, P39567, P38697 ];
GO:0003938 (F) IMP dehydrogenase activity [P50095, P50094, P39567, P38697 ];
GO:0055114 (P) oxidation reduction [P50095, P50094, P39567, P38697 ];
GO:0005737 (C) cytoplasm [P50095, P50094, P38697 ];
GO:0005515 (F) protein binding [P50095, P38697 ];

Links

SwissProt

P38697; P39567; P50094; P50095

Entrez Gene

851152; 854948; 856626



  Copyright 2009, Center for Bioinformatics 
  Last Modified: 2009-03-24  
  Design by Zhao Min