Center for Bioinformatics
Oxidoreductases | Transferases | Hydrolases | Lyases | Isomerases | Ligases

Basic Information

Enzyme Number

Official Name

thymidylate synthase

Name from literature

Thymidylate synthase

Pathway from literature

the synthesis of pyrimidine nucleotides

Pathway from KEGG

Metabolism of Cofactors and Vitamins; One carbon pool by folate; map00670

Nucleotide Metabolism; Pyrimidine metabolism; map00240


E.coli (83333)

Genome localization

-[949035 ],

Rate-limiting Description

"BACKGROUND: Thymidylate synthase (TS) is critical to DNA synthesis as it catalyzes the rate limiting step in the only biosynthetic pathway for deoxythymidine monophosphate (dTMP) production." (8805515)

Gene ontology

Gene ontology

GO:0006231 (P) dTMP biosynthetic process [P0A884 ];
GO:0004799 (F) thymidylate synthase activity [P0A884 ];
GO:0006417 (P) regulation of translation [P0A884 ];
GO:0005737 (C) cytoplasm [P0A884 ];
GO:0003723 (F) RNA binding [P0A884 ];

Subcellular localization


cytoplasm [P0A884 ];




Entrez Gene


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  Last Modified: 2009-03-24  
  Design by Zhao Min