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| Oxidoreductases | Transferases | Hydrolases | Lyases | Isomerases | Ligases |
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Basic Information |
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|---|---|
Enzyme Number | 2.1.1.45 |
Official Name | thymidylate synthase |
Name from literature | Thymidylate synthase |
Pathway from literature | the synthesis of pyrimidine nucleotides |
Pathway from KEGG |
Metabolism of Cofactors and Vitamins; One carbon pool by folate; map00670 |
| Nucleotide Metabolism; Pyrimidine metabolism; map00240 | |
Organisms | E.coli (83333) |
Genome localization | -[949035 ], |
Rate-limiting Description | "BACKGROUND: Thymidylate synthase (TS) is critical to DNA synthesis as it catalyzes the rate limiting step in the only biosynthetic pathway for deoxythymidine monophosphate (dTMP) production." (8805515) |
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Gene ontology |
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Gene ontology |
GO:0006231 (P) dTMP biosynthetic process [P0A884 ]; |
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Subcellular localization |
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Localization |
cytoplasm [P0A884 ]; |
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Links |
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SwissProt | |
Entrez Gene |