Center for Bioinformatics
Oxidoreductases | Transferases | Hydrolases | Lyases | Isomerases | Ligases

Basic Information

Enzyme Number

2.7.1.67

Official Name

1-phosphatidylinositol 4-kinase

Name from literature

phosphatidylinositol 4-kinase

Pathway from literature

production of phosphatidylinositol 4,5-bisphosphate

Pathway from KEGG

Environmental Information Processing; Signal Transduction; Phosphatidylinositol signaling system; map04070

Carbohydrate Metabolism; Inositol phosphate metabolism; map00562

Organisms

Rat (10116)

Genome localization

11q23[64161 ], 2q34[81747 ],

Comments

This reaction is catalysed by at least two different isoforms.

Rate-limiting Description

"As phosphatidylinositol 4-kinase is the rate-limiting enzyme for the production of phosphatidylinositol 4,5-bisphosphate, which is the preferred substrate for phospholipase C, we investigated the expression of phosphatidylinositol 4-kinase messenger RNA." (8190262)

Regulatory Information

Regulatory type

Detail

phosphorylation;

Q99M64:from_uniprot:43_Phosphoserine

phosphorylation;

Q99M64:from_uniprot:46_Phosphoserine

phosphorylation;

Q99M64:from_uniprot:461_Phosphoserine

phosphorylation;

Q99M64:from_uniprot:5_Phosphoserine

phosphorylation;

Q99M64:from_uniprot:50_Phosphoserine

phosphorylation;

Q99M64:from_uniprot:9_Phosphoserine

Gene ontology

Gene ontology

GO:0016020 (C) membrane [Q5XIL2 ];
GO:0046854 (P) phosphoinositide phosphorylation [O08561 ];
GO:0005737 (C) cytoplasm [Q99M64, Q5XIL2 ];
GO:0030867 (C) rough endoplasmic reticulum membrane [O08561 ];
GO:0005794 (C) Golgi apparatus [O08561 ];
GO:0004430 (F) 1-phosphatidylinositol 4-kinase activity [Q99M64, O08561, Q5XIL2 ];
GO:0048015 (P) phosphoinositide-mediated signaling [O08561 ];
GO:0005741 (C) mitochondrial outer membrane [O08561 ];

Subcellular localization

Localization

endosome [Q5XIL2 ];

cell membrane [Q99M64 ];

mitochondrion [O08561 ];

golgi apparatus [O08561, Q5XIL2 ];

endoplasmic reticulum [O08561 ];

membrane [O08561, Q5XIL2 ];

cytoplasm [Q99M64, Q5XIL2 ];

Links

SwissProt

O08561; Q5XIL2; Q99M64

Entrez Gene

64161; 81747



  Copyright 2009, Center for Bioinformatics 
  Last Modified: 2009-03-24  
  Design by Zhao Min