Center for Bioinformatics
Oxidoreductases | Transferases | Hydrolases | Lyases | Isomerases | Ligases

Basic Information

Enzyme Number

4.2.1.24

Official Name

porphobilinogen synthase

Name from literature

delta-aminolevulinic acid synthase

Pathway from literature

heme biosynthesis

Pathway from KEGG

Metabolism of Cofactors and Vitamins; Porphyrin and chlorophyll metabolism; map00860

Organisms

Rat (10116)

Genome localization

-[25374 ],

Comments

The fungal enzyme is a metalloprotein.

Rate-limiting Description

"The activities of delta-aminolevulinic acid synthase, a rate-limiting enzyme in the heme biosynthesis, and porphobilinogen synthase in the liver of rhIL-1beta-induced fevered rat were significantly lower than those in the control, whereas the activity of heme oxygenase, a key enzyme in the heme-degradative pathway, markedly increased in the fevered rat." (10634305)

"These data suggest that delta-aminolevulinic acid is an inappropriate precursor for studies of the rate of heme biosynthesis, presumably because it bypasses delta-aminolevulinic acid synthase, the physiological rate-limiting enzyme in the heme biosynthetic pathway." (1959865)

"The major differences between the flight group and the synchronous control were elevations in microsomal protein, liver glycogen content, tyrosine aminotransferase, and tryptophan oxygenase and reductions in sphingolipids and the rate-limiting enzyme of heme biosynthesis, delta-aminolevulinic acid synthase." (1526942)

Regulatory Information

Regulatory type

Detail

phosphorylation;

P06214

Gene ontology

Gene ontology

GO:0008270 (F) zinc ion binding [P06214 ];
GO:0006783 (P) heme biosynthetic process [P06214 ];
GO:0004655 (F) porphobilinogen synthase activity [P06214 ];

Links

SwissProt

P06214

Entrez Gene

25374



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  Last Modified: 2009-03-24  
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