Center for Bioinformatics
Oxidoreductases | Transferases | Hydrolases | Lyases | Isomerases | Ligases

Basic Information

Enzyme Number

3.1.3.9

Official Name

glucose-6-phosphatase

Name from literature

Glucose-6-phosphatase

Pathway from literature

gluconeogenesis

Pathway from KEGG

Cellular Processes; Endocrine System; Insulin signaling pathway; map04910

Cellular Processes; Endocrine System; Adipocytokine signaling pathway; map04920

Carbohydrate Metabolism; Starch and sucrose metabolism; map00500

Carbohydrate Metabolism; Glycolysis / Gluconeogenesis; map00010

Carbohydrate Metabolism; Galactose metabolism; map00052

Organisms

Rat (10116)

Genome localization

10q32.1[25634 ],

Comments

Wide distribution in animal tissues. Also catalyses potent transphosphorylations from carbamoyl phosphate, hexose phosphates, diphosphate, phosphoenolpyruvate and nucleoside di- and triphosphates, to D-glucose, D-mannose, 3-methyl-D-glucose or 2-deoxy-D-glucose [cf. EC 2.7.1.62 (phosphoramidate---hexose phosphotransferase), EC 2.7.1.79 (diphosphate---glycerol phosphotransferase) and EC 3.9.1.1 (phosphoamidase)].

Rate-limiting Description

"Expression of glucose-6-phosphatase (G6Pase), one of the rate-limiting enzymes of hepatic gluconeogenesis, has recently been shown to be transactivated by the transcription factor FKHR." (12507516)

Regulatory Information

Upstream transcription factor

24817;81646;25735;25620;24252

Regulatory type

Detail

transcriptional factor;HNF4alpha(25735)

"glucose-6-phosphatase gene expression in cultured hepatocytes and H4IIE cells is regulated by short-chain fatty acids and HNF-4alpha" (12915406)

transcriptional factor;"HNF4alpha(25735),C/EBP,CREB(81646)"

"the cAMP responsiveness of the Glc6Pase promoter requires a tight cooperation between a proximal and a distal region, which depends on the presence of several HNF4alpha-, C/EBP-, and CREB-binding sites" (15388792)

transcriptional factor;"HNF4alpha(25735),CREM(25620),HNF1alpha(24817),C/EBPalpha(24252)"

"HNF4alpha, CREM, HNF1alpha, and C/EBPalpha have roles in transcriptional regulation of the glucose-6-phosphatase gene by cAMP/vasoactive intestinal peptide in the intestine" (16893891)

Gene ontology

Gene ontology

GO:0004346 (F) glucose-6-phosphatase activity [P43428, Q6AZ83 ];
GO:0016021 (C) integral to membrane [P43428, Q6AZ83 ];
GO:0006094 (P) gluconeogenesis [P43428, Q6AZ83 ];
GO:0005789 (C) endoplasmic reticulum membrane [P43428, Q6AZ83 ];

Subcellular localization

Localization

endoplasmic reticulum [P43428, Q6AZ83 ];

Links

SwissProt

P43428; Q6AZ83

Entrez Gene

25634



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  Last Modified: 2009-03-24  
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