Center for Bioinformatics
Oxidoreductases | Transferases | Hydrolases | Lyases | Isomerases | Ligases

Basic Information

Enzyme Number

1.3.3.3

Official Name

coproporphyrinogen oxidase

Name from literature

coproporphyrinogen oxidase

Pathway from literature

heme synthesis

Pathway from KEGG

Metabolism of Cofactors and Vitamins; Porphyrin and chlorophyll metabolism; map00860

Organisms

Mouse (10090)

Genome localization

-[12892 ],

Rate-limiting Description

"While ALAS induction is necessary for increased heme synthesis, these data indicate that other enzymes, in particular coproporphyrinogen oxidase, represent down-stream rate-limiting steps." (11368326)

Regulatory Information

Regulatory type

Detail

phosphorylation;

P36552:from_uniprot:99_Phosphoserine

Gene ontology

Gene ontology

GO:0006783 (P) heme biosynthetic process [P36552 ];
GO:0005758 (C) mitochondrial intermembrane space [P36552 ];
GO:0004109 (F) coproporphyrinogen oxidase activity [P36552 ];
GO:0055114 (P) oxidation reduction [P36552 ];

Subcellular localization

Localization

mitochondrion [P36552 ];

Links

SwissProt

P36552

Entrez Gene

12892



  Copyright 2009, Center for Bioinformatics 
  Last Modified: 2009-03-24  
  Design by Zhao Min