Center for Bioinformatics
Oxidoreductases | Transferases | Hydrolases | Lyases | Isomerases | Ligases

Basic Information

Enzyme Number

1.1.1.49

Official Name

glucose-6-phosphate dehydrogenase

Name from literature

glucose-6-phosphate dehydrogenase

Pathway from literature

pentose phosphate pathway (PPP)/the GSH- and NADPH-dependent H(2)O(2) elimination by PC12 cells/NADPH production

Pathway from KEGG

Metabolism of Other Amino Acids; Glutathione metabolism; map00480

Carbohydrate Metabolism; Pentose phosphate pathway; map00030

Organisms

Mouse (10090)

Genome localization

5 C3.1|5 39.0 cM[14380 ], X A2-A3|X 30.02 cM[14381 ],

Comments

Also acts slowly on beta-D-glucose and other sugars. Certain preparations reduce NAD+ as well as NADP+.

Rate-limiting Description

"Quantitation of liver mRNA levels shows that, during the transition from light to dark period, tubby mice fail to induce glucose-6-phosphate dehydrogenase (G6pdh), the rate-limiting enzyme in the pentose phosphate pathway that normally supplies NADPH for de novo fatty acid synthesis and glutathione reduction." (16849632)

"Glucose-6-phosphate dehydrogenase (G6PD) functions as the first and rate-limiting enzyme in the pentose phosphate pathway, responsible for the generation of NADPH in a reaction coupled to the de novo production of cellular ribose." (12829617)

"Glucose-6-phosphate dehydrogenase (G6PD), the rate-limiting enzyme in the pentose phosphate pathway, generates NADPH in a reaction linked to the de novo production of ribose." (14757696)

Regulatory Information

Regulatory type

Detail

phosphorylation;

Q00612

phosphorylation;

Q00612:from_uniprot:401_Phosphotyrosine

phosphorylation;

Q00612:from_uniprot:503_Phosphotyrosine

phosphorylation;

Q00612:from_uniprot:507_Phosphotyrosine

transcriptional level;

"Moreover, elements involved in the regulation of lipogenesis like USF (Upstream stimulating factor), HSF (Heat Shock Factor), F2F (Prolactin receptor), RAR (Retinoid Acid Receptor), STRE (STress Response Element), RORa (Retinoid related Orphan Receptor alpha), GATA (GATA binding factor), RFX (Regulatory Factor X), SREBP (Sterol Regulatory Element Binding Protein), MEP (Metal Element Protein), CREB (insulin receptor), PRE (Progesterone receptor), and HNF4 (Hepatic Nuclear Factor 4) were detected. The most important regulatory motifs were found to be conserved as compared to those in human and mouse counterparts. " (17493856)

Gene ontology

Gene ontology

GO:0002033 (P) vasodilation by angiotensin involved in reg... [Q00612 ];
GO:0032613 (P) interleukin-10 production [Q00612 ];
GO:0006006 (P) glucose metabolic process [Q0VB18, Q00612, P97324, A3KG36, A0FF38, Q3TNL1, Q790Y8 ];
GO:0004345 (F) glucose-6-phosphate dehydrogenase activity [Q0VB18, Q00612, P97324, A3KG36, A0FF38, Q3TNL1, Q790Y8 ];
GO:0048821 (P) erythrocyte development [Q00612 ];
GO:0042803 (F) protein homodimerization activity [Q00612 ];
GO:0019322 (P) pentose biosynthetic process [Q00612 ];
GO:0006979 (P) response to oxidative stress [Q00612 ];
GO:0006741 (P) NADP biosynthetic process [Q00612 ];
GO:0040014 (P) regulation of multicellular organism growth [Q00612 ];
GO:0032615 (P) interleukin-12 production [Q00612 ];
GO:0001998 (P) angiotensin mediated vasoconstriction invol... [Q00612 ];
GO:0006749 (P) glutathione metabolic process [Q00612 ];
GO:0005488 (F) binding [Q0VB18, P97324, A3KG36, A0FF38, Q3TNL1, Q790Y8 ];
GO:0055114 (P) oxidation reduction [Q0VB18, Q00612, P97324, A3KG36, A0FF38, Q3TNL1, Q790Y8 ];

Links

SwissProt

A0FF38; A3KG36; P97324; Q00612; Q0VB18; Q3TNL1; Q790Y8

Entrez Gene

14380; 14381



  Copyright 2009, Center for Bioinformatics 
  Last Modified: 2009-03-24  
  Design by Zhao Min